Near real-time severe acute respiratory illness surveillance characterising influenza and COVID-19 epidemiology in hospitalised adults, 2021-22

IF 14.3 1区医学 Q1 INFECTIOUS DISEASES

Journal of Infection Pub Date : 2024-11-01 DOI:10.1016/j.jinf.2024.106338

Antonia Ho , Neil McInnes , Andrew Blunsum , Joanna Quinn , Daniel Lynagh , Michael E. Murphy , Rory Gunson , Alisdair MacConnachie , David J. Lowe

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引用次数: 0

Abstract

Objectives

We report the findings of a novel enhanced syndromic surveillance that characterised influenza- and SARS-CoV-2-associated severe acute respiratory illness (SARI) in the 2021/2022 winter season.

Methods

Prospective cohort study of adults admitted to the Queen Elizabeth University Hospital, Glasgow, with a severe acute respiratory illness. Patient demographics, clinical history, admission details, and outcomes were recorded. Data were available to Public Health Scotland (PHS) and clinicians weekly.

Results

Between November 2021 and May 2022, 1063 hospitalised SARI episodes in 1037 adult patients were identified. Median age was 72.0 years, and 44.5% were male. Most (82.6%) SARI cases had ≥1 co-morbidity; chronic lung disease (50.0%) and malignancy (22.5%) were the most frequently reported.

Overall, 229 (22%) and 33 (3%) SARI episodes were SARS-CoV-2 and influenza A PCR positive, respectively. 74.7%, 6.5% and 43.0% SARI episodes received antibiotics, antivirals, and steroids, respectively (54.5%, 11.0% and 51.3% among COVID-19 patients). 1.1% required mechanical ventilation and 7.8% died. Male sex, multimorbidity, frailty, respiratory rate >30, low GCS and chest X-ray consolidation were predictive of in-hospital mortality.

Conclusion

Near real-time hospitalised SARI syndromic surveillance characterised the evolving clinical epidemiology of SARS-CoV-2 and influenza, high antimicrobial use, and predictors of inpatient mortality among hospitalised SARI patients.

查看原文本刊更多论文

近实时严重急性呼吸道疾病监测，描述 2021-22 年住院成人流感和 COVID-19 流行病学特征。

目的我们报告了一项新型强化综合征监测的结果，该监测描述了 2021/2022 年冬季流感和 SARS-CoV-2 相关严重急性呼吸道疾病（SARI）的特征：对格拉斯哥伊丽莎白女王大学医院收治的患有严重急性呼吸道疾病的成人进行前瞻性队列研究。研究记录了患者的人口统计学特征、临床病史、入院详情和结果。苏格兰公共卫生署（PHS）和临床医生每周都能获得相关数据：结果：2021 年 11 月至 2022 年 5 月期间，确定了 1037 名成年患者的 1063 例 SARI 住院病例。中位年龄为 72.0 岁，44.5% 为男性。大多数 SARI 病例（82.6%）有 1 种以上的并发症；慢性肺病（50.0%）和恶性肿瘤（22.5%）是最常见的并发症。总体而言，SARS-CoV-2 和甲型流感 PCR 阳性的 SARI 病例分别为 229 例（22%）和 33 例（3%）。74.7%、6.5% 和 43.0% 的 SARI 患者分别接受了抗生素、抗病毒药物和类固醇治疗（COVID-19 患者中分别为 54.5%、11.0% 和 51.3%）。1.1%的患者需要机械通气，7.8%的患者死亡。男性、多病、体弱、呼吸频率大于 30、GCS 低和胸部 X 光片合并症可预测院内死亡率：结论：近乎实时的住院 SARI 综合征监测描述了不断变化的 SARS-CoV-2 和流感临床流行病学、抗菌药物的大量使用以及住院 SARI 患者的住院死亡率预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection 医学-传染病学

CiteScore

45.90

自引率

3.20%

发文量

475

审稿时长

16 days

期刊介绍： The Journal of Infection publishes original papers on all aspects of infection - clinical, microbiological and epidemiological. The Journal seeks to bring together knowledge from all specialties involved in infection research and clinical practice, and present the best work in the ever-changing field of infection. Each issue brings you Editorials that describe current or controversial topics of interest, high quality Reviews to keep you in touch with the latest developments in specific fields of interest, an Epidemiology section reporting studies in the hospital and the general community, and a lively correspondence section.