Case study: May human norovirus infection be associated with premature delivery?

IF 5.5 3区 医学 Q1 Medicine
Jiaying Cao, Yuetong Li, Feiyang Xue, Ziyang Sheng, Libo Liu, Yingying Zhang, Lele Wang, Liang Zeng, Yanmin Jiang, Dongying Fan, Fang Li, Jing An
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Abstract

Human norovirus (HuNoV) is the leading cause of acute gastroenteritis. The varying severity of chronic infection in patients with underlying immune deficiencies poses additional burdens on public health. However, the potential effects of HuNoV infection during pregnancy, a specific immune perturbed state, have been rarely reported. Recently, four cases of HuNoV-infected patients in the late stages of pregnancy were admitted to the Guangzhou Women and Children's Medical Center, and premature rupture of membranes as primary adverse outcome was observed in these cases. Samples of fetal accessory tissue were collected from two of these cases at delivery to explore the potential pathogenesis. Pathological analysis showed placental malperfusion in both maternal and fetal vascular, while a decrease in vessels was not observed in villi of placenta. There was obvious pathological change in the chorion of fetal membrane, accompanied by a tendency of Th-1 immune bias. Notably, aggregation of M2 macrophages was observed in the chorion of the fetal membrane, potentially recruited for tissue repair. Next-generation sequencing showed minimal changes in immune pathways within placenta tissue. A gene panel associated with immunosuppression was identified in the fetal membrane of HuNoV-infected women compared to those of normal parturient. Taken together, this study provides clues for the association between the HuNoV and premature delivery, which requires the attention of the clinicians.

病例研究:人类诺如病毒感染可能与早产有关吗?
人类诺如病毒(HuNoV)是急性肠胃炎的主要病因。潜在免疫缺陷患者慢性感染的严重程度各不相同,给公共卫生带来了额外负担。然而,关于妊娠期(一种特殊的免疫紊乱状态)感染 HuNoV 的潜在影响却鲜有报道。最近,广州市妇女儿童医疗中心收治了四例妊娠晚期的 HuNoV 感染者,这些病例均以胎膜早破为主要不良结局。为了探究潜在的发病机制,我们在其中两例患者分娩时采集了胎儿附属组织样本。病理分析显示,母体和胎儿的血管均出现胎盘灌注不良,而胎盘绒毛中的血管并未减少。胎膜绒毛有明显的病理变化,并伴有 Th-1 免疫倾向。值得注意的是,在胎膜绒毛中观察到 M2 巨噬细胞的聚集,它们可能被用于组织修复。下一代测序显示胎盘组织内的免疫途径变化极小。与正常产妇的胎膜相比,HuNoV 感染产妇的胎膜中发现了与免疫抑制相关的基因群。综上所述,这项研究为胡诺夫病毒与早产之间的关联提供了线索,需要引起临床医生的注意。
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来源期刊
Virologica Sinica
Virologica Sinica Biochemistry, Genetics and Molecular Biology-Molecular Medicine
CiteScore
7.70
自引率
1.80%
发文量
3149
期刊介绍: Virologica Sinica is an international journal which aims at presenting the cutting-edge research on viruses all over the world. The journal publishes peer-reviewed original research articles, reviews, and letters to the editor, to encompass the latest developments in all branches of virology, including research on animal, plant and microbe viruses. The journal welcomes articles on virus discovery and characterization, viral epidemiology, viral pathogenesis, virus-host interaction, vaccine development, antiviral agents and therapies, and virus related bio-techniques. Virologica Sinica, the official journal of Chinese Society for Microbiology, will serve as a platform for the communication and exchange of academic information and ideas in an international context. Electronic ISSN: 1995-820X; Print ISSN: 1674-0769
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