Mixed Gangliocytoma-Pituitary Adenoma: A Systematic Review of Diagnostic Features, Clinical Management, and Surgical Outcomes.

IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY
World neurosurgery Pub Date : 2025-01-01 Epub Date: 2024-11-13 DOI:10.1016/j.wneu.2024.10.051
Kishore Balasubramanian, Romulo Augusto Andrade de Almeida, Abdurrahman F Kharbat, Ali S Haider, Ian F Dunn, Christopher S Graffeo
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引用次数: 0

Abstract

Objective: Mixed gangliocytoma-pituitary adenomas (MGPAs) are very rare sellar neoplasms. Contemporary understanding of their natural history, clinical characteristics, optimal management strategies, and prototypical outcomes remains poorly understood.

Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, PubMed, Embase, Web of Science, and Cochrane were searched to include studies of patients with histologically confirmed mixed gangliocytomas. Clinical features, management strategies, and outcomes were analyzed.

Results: Thirty three studies reporting 78 patients met study criteria and were included. Median age at diagnosis was 47 years, with a female predominance (71%). Common presenting symptoms included headache (49%), acromegaly (43%), and visual disturbance (20%). Growth hormone and prolactin were the most commonly elevated hormones. Magnetic resonance imaging identified local infiltration in 86% of patients, most frequently in the cavernous sinus. Transsphenoidal resection was the primary treatment strategy, which achieved a gross total resection in 43%. Postoperative pituitary function was normal in 92%. Median follow-up was 21 months, during which time 14% of patients required secondary intervention for persistent hormonal hypersecretion. Following these secondary interventions and as of last follow-up, radiographic and/or biochemical control was confirmed in all patients, with an overall survival rate of 97%.

Conclusions: MGPAs are rare, slow-growing tumors that present with a combination of endocrinological and neurological symptoms. MGPAs are optimally managed with transsphenoidal resection, which appears to achieve favorable rates of symptomatic relief and local control despite the high incidence of local infiltration and relatively low attendant gross total resection rate.

混合性神经节细胞瘤-垂体腺瘤:诊断特征、临床管理和手术结果的系统性回顾。
目的:混合性神经节细胞瘤-垂体腺瘤(MGPAs)是非常罕见的蝶窦肿瘤。目前,人们对它们的自然史、临床特征、最佳治疗策略和原型结果仍知之甚少:按照系统综述和荟萃分析首选报告项目(PRISMA)指南,对 PubMed、EMBASE、Web of Science 和 Cochrane 进行了检索,以纳入经组织学证实的混合神经节细胞瘤(MGPAs)患者的研究。对临床特征、管理策略和结果进行了分析:33项研究报告了78名患者,符合研究标准并被纳入。确诊时的中位年龄为47岁,女性占多数(71%)。常见症状包括头痛(49%)、肢端肥大症(43%)和视力障碍(20%)。生长激素(GH)和催乳素是最常见的升高激素。磁共振成像(MRI)发现,86%的患者有局部浸润,最常见的是海绵窦。经蝶窦切除术是主要的治疗策略,43%的患者实现了全切除(GTR)。92%的患者术后垂体功能正常。中位随访时间为21个月,在此期间,14%的患者因持续激素分泌过多而需要二次干预。经过这些二次干预后,截至最后一次随访,所有患者的放射学和/或生化指标均得到控制,总生存率达到97%:结论:MGPA是一种罕见的生长缓慢的肿瘤,同时伴有内分泌和神经系统症状。经蝶窦切除术是治疗MGPA的最佳方法,尽管局部浸润的发生率较高,GTR率相对较低,但该手术似乎能取得良好的症状缓解率和局部控制率。
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来源期刊
World neurosurgery
World neurosurgery CLINICAL NEUROLOGY-SURGERY
CiteScore
3.90
自引率
15.00%
发文量
1765
审稿时长
47 days
期刊介绍: World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The journal''s mission is to: -To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care. -To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide. -To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients. Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS
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