Heart is a heavy burden: cardiac toxicity in radiation oncology.

IF 2.8 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Pierre Pouvreau, Imed Taleb, Agathe Fontaine, Lucas Edouard, Nyere Gibson, Margaux Yaouanq, Augustin Boudoussier, Adeline Petit, Vincent Vinh-Hung, Paul Sargos, Nicolas Benziane-Ouaritini, Wafa Bouleftour, Nicolas Magne
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引用次数: 0

Abstract

Over the years, radiotherapy has seen continual improvements and has become a standard treatment for most malignant tumors. Cardiotoxicity is a well-known radiotherapy side effect, leading to the risk of long-term morbidity and mortality in cancer survivors. Therefore, minimizing radiotherapy-related cardiotoxicity remains an important challenge in cancer care management. Indeed, multiple dose constraints were proposed for the heart and its substructures. In addition, sparing techniques were developed to reduce the exposure of the heart to ionizing radiation and are currently used in daily clinical routine. The purpose of this review is to summarize the current knowledge about radiation-induced cardiotoxicity, to discuss the previously cardiac dose constraints, and to evaluate the various management strategies.

心脏是沉重的负担:放射肿瘤学中的心脏毒性。
多年来,放射治疗不断改进,已成为治疗大多数恶性肿瘤的标准疗法。心脏毒性是众所周知的放疗副作用,会导致癌症幸存者长期发病和死亡。因此,尽量减少与放疗相关的心脏毒性仍是癌症护理管理中的一项重要挑战。事实上,针对心脏及其附属结构提出了多种剂量限制。此外,人们还开发了疏导技术,以减少电离辐射对心脏的照射,这些技术目前已用于日常临床工作中。本综述旨在总结目前有关辐射诱发心脏毒性的知识,讨论之前的心脏剂量限制,并评估各种管理策略。
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来源期刊
Supportive Care in Cancer
Supportive Care in Cancer 医学-康复医学
CiteScore
5.70
自引率
9.70%
发文量
751
审稿时长
3 months
期刊介绍: Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It covers primarily medical, technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease. Nursing, rehabilitative, psychosocial and spiritual issues of support are also included.
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