Quercetin protects the liver of broiler chicken against oxidative stress and apoptosis induced by ochratoxin A

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Toxicon Pub Date : 2024-11-01 DOI:10.1016/j.toxicon.2024.108160

Abdel Azeim A. Khalaf , Mohamed A. Elhady , Marwa A. Ibrahim , Eman I. Hassanen , Rehab E. Abdelrahman , Peter A. Noshy

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引用次数: 0

Abstract

Ochratoxin A (OTA) is a mycotoxin that causes major health concerns in human and animals. Quercetin (QUE) is a flavonoid that possesses antioxidant, anti-inflammatory and anti-apoptotic properties. This report aims to investigate the ameliorative effects of QUE against OTA-induced hepatotoxicity in broiler chicken. Forty broiler chicks were equally allocated into 4 groups: Group I (control), Group II (OTA), Group III (QUE) and Group IV (OTA + QUE). OTA (0.5 mg/kg) and QUE (0.5 g/kg) were incorporated into the chicken feed for 42 days. The results presented a significant decrease in body weight and elevation in feed conversion ratio, and a significant elevation of the activities of serum alanine aminotransferase and aspartate aminotransferase enzymes in the OTA birds. Additionally, there was a significant decrease in catalase activity and reduced glutathione content and a significant elevation in malondialdehyde level in the liver of OTA-exposed birds. Various hepatocellular lesions were also noticed in the OTA-exposed birds. OTA exposure up-regulated the phosphatase and tensin homologue (PTEN) and the pro-apoptotic genes and down-regulated the anti-apoptotic genes in the liver. The addition of QUE ameliorated most of the hepatotoxic effects of OTA.

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槲皮素可保护肉鸡肝脏免受赭曲霉毒素 A 诱导的氧化应激和细胞凋亡的影响。

赭曲霉毒素 A（OTA）是一种霉菌毒素，对人类和动物的健康造成严重危害。槲皮素（QUE）是一种类黄酮，具有抗氧化、抗炎和抗细胞凋亡的特性。本报告旨在研究槲皮素对 OTA 引起的肉鸡肝中毒的改善作用。将 40 只肉鸡平均分为 4 组：第一组（对照组）、第二组（OTA）、第三组（QUE）和第四组（OTA+QUE）。在鸡饲料中添加 OTA（0.5 毫克/千克）和 QUE（0.5 克/千克），持续 42 天。结果显示，OTA 组鸡的体重明显下降，饲料转化率明显提高，血清丙氨酸氨基转移酶和天门冬氨酸氨基转移酶的活性明显升高。此外，受 OTA 影响的禽类肝脏中过氧化氢酶活性和还原型谷胱甘肽含量显著下降，丙二醛含量显著升高。暴露于 OTA 的鸟类还出现了各种肝细胞病变。暴露于 OTA 会上调肝脏中的磷酸酶和天丝同源物（PTEN）以及促凋亡基因，下调抗凋亡基因。添加 QUE 可改善 OTA 的大部分肝毒性效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicon 医学-毒理学

CiteScore

4.80

自引率

10.70%

发文量

358

审稿时长

68 days

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