Genetic Polymorphism in miRNA Genes and Their Association with susceptibility of Coronary Heart Disease: anAn Updated Rreview

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2024-10-30 DOI:10.1016/j.prp.2024.155675

Khalid Khan , Aakif khan , Zia Ur Rahman , Faisal Khan , Noreen Latief , Numan Fazal

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Abstract

Coronary heart disease (CHD) remains a major public health concern worldwide, with a complex interplay of genetic, environmental and lifestyle factors contributing to its pathogenesis. The potential significance of microRNAs (miRNAs) in the onset and progression of CHD has attracted increasing attention in recent years. Small non-coding RNA molecules called miRNAs control gene expression at the post-transcriptional level. Dysregulation of miRNAs has been linked to a variety of biological processes, including cell division, proliferation, apoptosis, and inflammation. Numerous research studies have looked into the relationship between genetic variants in miRNA genes and CHD susceptibility. This review highlights the recent research work carried out to identify the relationship of miRNA genes polymorphism with the progression and susceptibility of CHD. Such studies could pave the way for the development of personalized strategies for CHD prevention and treatment based on an individual's genetic profile.

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miRNA 基因的遗传多态性及其与冠心病易感性的关系：最新综述。

冠心病（CHD）仍然是全球关注的主要公共卫生问题，其发病机制是由遗传、环境和生活方式等因素复杂地相互作用造成的。近年来，微小核糖核酸（miRNA）在冠心病发病和发展过程中的潜在意义日益受到关注。被称为 miRNA 的非编码 RNA 小分子在转录后水平控制基因表达。miRNA 的失调与多种生物过程有关，包括细胞分裂、增殖、凋亡和炎症。许多研究探讨了 miRNA 基因中的遗传变异与冠心病易感性之间的关系。本综述重点介绍了近期为确定 miRNA 基因多态性与冠心病进展和易感性之间的关系而开展的研究工作。这些研究可为根据个体的遗传特征制定个性化的冠心病预防和治疗策略铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.