Insecticide-treated bednets and chemoprophylaxis reduce malaria mortality and parasite prevalence.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-11-04 DOI:10.1093/trstmh/trae090

Thomas J Peto

引用次数: 0

Abstract

This commentary discusses an influential study from 1993 that demonstrated, among West African children, an overall mortality benefit of insecticide-impregnated bednets, and the reduction of malaria prevalence by chemoprophylaxis. Led by Brian Greenwood and colleagues in The Gambia, the trial also showed these tools to be affordable and practicable. In the years since, >2 billion bednets have been provided to high-risk populations and have contributed greatly to reductions in malaria-attributable mortality. Seasonal malaria chemoprevention now protects 50 million African children annually. Few interventions in tropical medicine have achieved such an impact.

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驱虫蚊帐和化学预防可降低疟疾死亡率和寄生虫感染率。

这篇评论讨论了 1993 年一项颇具影响力的研究，该研究表明，在西非儿童中，使用杀虫剂浸泡过的蚊帐可降低总体死亡率，并通过化学预防降低疟疾流行率。该试验由布莱恩-格林伍德及其在冈比亚的同事领导，试验还表明这些工具是负担得起和切实可行的。此后的几年里，已向高危人群提供了超过 20 亿顶蚊帐，为降低疟疾导致的死亡率做出了巨大贡献。现在，季节性疟疾化学预防每年可保护 5000 万非洲儿童。热带医学中很少有干预措施能产生如此大的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.