Early gastric composite tumor comprising signet-ring cell carcinoma and mucosa-associated lymphoid tissue lymphoma: A case report.

IF 4.3 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

World Journal of Gastroenterology Pub Date : 2024-10-14 DOI:10.3748/wjg.v30.i38.4232

Yi-Fan Jia, Fei-Fan Chen, Li Yang, Yun-Xia Ye, Yi-Zhu Gao, Wen-Yan Zhang, Jin-Lin Yang

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Abstract

Background: Composite tumors are neoplasms comprising two distinct, yet intermingling, cell populations. This paper reports a rare phenomenon where early gastric signet-ring cell carcinoma (SRCC) and gastric mucosa-associated lymphoid tissue (MALT) lymphoma coexist within the same lesion.

Case summary: A 40-year-old woman presented to the West China Hospital for examination, which revealed a whitish, shallow, and uneven mucosal lesion in the stomach. The lesion was diagnosed as a poorly differentiated adenocarcinoma, including SRCC with atypical lymphoid hyperplasia associated with Helicobacter pylori infection, based on histopathological examination of the biopsy specimen. The lesion was excised using segmental gastrectomy. However, histological examination of the surgical specimen confirmed that it was a poorly differentiated gastric adenocarcinoma with features of SRCC and MALT lymphoma. These two entities were stage I and coexisted in the same lesion.

Conclusion: It is uncommon for gastric SRCC and MALT lymphoma to coexist without distinct borders. Surgical resection is effective for these lesions.

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由标志环细胞癌和粘膜相关淋巴组织淋巴瘤组成的早期胃复合瘤：病例报告。

背景：复合瘤是由两种截然不同但又相互混合的细胞群组成的肿瘤。本文报告了一种罕见的现象，即早期胃标志环细胞癌（SRCC）和胃黏膜相关淋巴组织（MALT）淋巴瘤共存于同一病变中。病例摘要：一名 40 岁的女性到华西医院就诊，检查发现胃黏膜病变呈白色、浅表、凹凸不平。根据活检标本的组织病理学检查，该病变被诊断为分化较差的腺癌，包括与幽门螺杆菌感染相关的伴有非典型淋巴增生的 SRCC。该患者的病灶通过分段胃切除术切除。然而，手术标本的组织学检查证实，这是一种分化较差的胃腺癌，具有 SRCC 和 MALT 淋巴瘤的特征。结论：胃 SRCC 并不常见：胃SRCC和MALT淋巴瘤并存且无明显边界的情况并不常见。手术切除对这些病变很有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

7.80

自引率

4.70%

发文量

464

审稿时长

2.4 months

期刊介绍： The primary aims of the WJG are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in gastroenterology and hepatology.