Cognitive behavioral therapy combined with selective serotonin reuptake inhibitors for premature ejaculation: A systematic review and meta-analysis.

IF 3.2 2区 医学 Q1 ANDROLOGY
Andrology Pub Date : 2024-11-03 DOI:10.1111/andr.13787
Liang Li, Hao Geng, Meng Chen, Wei Hu, Qinglin Ye
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引用次数: 0

Abstract

Background: Premature ejaculation (PE) remains one of the most common male disorders. Many clinical trials have shown that cognitive behavioral therapy (CBT) has significant efficacy in the treatment of PE. The purpose of this article is to review the current evidence regarding the efficacy and safety of CBT combined with selective serotonin reuptake inhibitors (SSRIs) for treating PE.

Methods: We selected eligible randomized controlled trials (RCTs) from databases including Chinese National Knowledge Infrastructure (CNKI), Wanfang, VIP, China Biology Medicine (CBM), Pubmed, Embase, and Cochrane Library. All data in this paper were analyzed using STATA 17.1 software. Cochrane Evaluator's Manual 5.3 was used to assess the quality of the included literature. Data collection was conducted up until May 2024.

Results: Finally, 15 high-quality randomized controlled trials were included, with 1243 patients, 653 experimental groups and 590 control groups. The meta-analysis showed that, compared with SSRIs alone, behavioral therapy combined with SSRIs can significantly prolong the IELT of PE patients, and improve perceived control over ejaculation, Chinese Index of Premature ejaculation-5 (CIPE-5), sexual life satisfaction, and spouses' sexual life satisfaction. Furthermore, there were no significant differences in side effects between the two groups. In addition, the published bias test results showed no significant bias.

Conclusion: CBT combined with SSRIs could be a viable alternative for the treatment of PE. Both cognitive and behavioral training or behavioral training alone as a supplement to SSRIs are effective, with no significant increase in adverse reactions.

认知行为疗法与选择性血清素再摄取抑制剂联合治疗早泄:系统回顾和荟萃分析。
背景:早泄(PE)仍然是最常见的男性疾病之一。许多临床试验表明,认知行为疗法(CBT)对治疗早泄有显著疗效。本文旨在回顾目前有关CBT联合选择性5-羟色胺再摄取抑制剂(SSRIs)治疗早泄的有效性和安全性的证据:我们从中国国家知识基础设施(CNKI)、万方数据库、VIP数据库、中国生物医学数据库(CBM)、Pubmed数据库、Embase数据库和Cochrane图书馆等数据库中筛选出符合条件的随机对照试验(RCT)。本文所有数据均使用 STATA 17.1 软件进行分析。Cochrane Evaluator's Manual 5.3 用于评估纳入文献的质量。数据收集工作一直持续到 2024 年 5 月:最后,共纳入 15 项高质量的随机对照试验,包括 1243 名患者、653 个实验组和 590 个对照组。荟萃分析表明,与单用SSRIs相比,行为疗法联合SSRIs能显著延长PE患者的IELT,改善射精控制感、中国早泄指数-5(CIPE-5)、性生活满意度和配偶的性生活满意度。此外,两组患者的副作用无明显差异。此外,已发表的偏倚测试结果显示无明显偏倚:结论:CBT 联合 SSRIs 是治疗 PE 的可行替代方案。认知和行为训练或单独的行为训练作为SSRIs的补充均有效,且不良反应无明显增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Andrology
Andrology ANDROLOGY-
CiteScore
9.10
自引率
6.70%
发文量
200
期刊介绍: Andrology is the study of the male reproductive system and other male gender related health issues. Andrology deals with basic and clinical aspects of the male reproductive system (gonads, endocrine and accessory organs) in all species, including the diagnosis and treatment of medical problems associated with sexual development, infertility, sexual dysfunction, sex hormone action and other urological problems. In medicine, Andrology as a specialty is a recent development, as it had previously been considered a subspecialty of urology or endocrinology
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