Changes in Oxidative Stress Markers in Pregnant Women of Advanced Maternal Age with Gestational Diabetes and Their Predictive Value for Neurodevelopmental Impact.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2024-10-29 eCollection Date: 2024-01-01 DOI:10.2147/DMSO.S475385

Yabing Wang, Zhenling Fan, Jianli Ren, Lin Ma

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Abstract

Objective: To explore the relationship between changes in oxidative stress markers in pregnant women of advanced maternal age with gestational diabetes mellitus (GDM) and adverse pregnancy outcomes and neonatal neurodevelopment, as well as their predictive value.

Methods: Two hundred pregnant women of advanced maternal age were selected and divided into Group A (normal blood sugar) and Group B (GDM) based on the 75 g (Oral Glucose Tolerance Test) OGTT results. Oxidative stress markers were measured, and pregnancy outcomes and neonatal Neonatal Behavioral Assessment Scale (NABA) scores were recorded.

Results: Malondialdehyde (MDA) levels in Group B were higher than those in Group A, while Glutathione (GSH) and Superoxide Dismutase (SOD) levels were lower. Group B had higher rates of adverse pregnancy outcomes and neurological abnormalities than Group A. The Area Under the Curve (AUC) values for serum MDA, GSH, and SOD levels combined prediction were higher than those for individual predictions (P<0.05).

Conclusion: Oxidative stress markers in pregnant women of advanced maternal age with GDM are associated with adverse pregnancy outcomes and neonatal abnormalities, and combined prediction has good predictive efficiency (AUC>0.7).

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妊娠糖尿病高龄孕妇体内氧化应激标记物的变化及其对神经发育影响的预测价值

目的探讨妊娠期糖尿病（GDM）高龄孕妇氧化应激标志物的变化与不良妊娠结局和新生儿神经发育的关系及其预测价值：方法：选取 200 名高龄孕妇，根据 75 g（口服葡萄糖耐量试验）OGTT 结果分为 A 组（血糖正常）和 B 组（GDM）。测量氧化应激标记物，记录妊娠结局和新生儿行为评估量表（NABA）评分：结果：B组的丙二醛（MDA）水平高于A组，而谷胱甘肽（GSH）和超氧化物歧化酶（SOD）水平较低。血清 MDA、GSH 和 SOD 水平综合预测的曲线下面积（AUC）值高于单独预测的曲线下面积（PConclusion：GDM高龄孕妇的氧化应激标记物与不良妊娠结局和新生儿畸形有关，联合预测具有良好的预测效率（AUC>0.7）。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.