High Prevalence of Carbapenem-resistant Klebsiella Pneumoniae in Fecal and Water Samples in Dhaka, Bangladesh.

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2024-10-11 eCollection Date: 2024-11-01 DOI:10.1093/ofid/ofae612

Sanchita Kar, Zannat Kawser, Sushmita Sridhar, Sharmin Aktar Mukta, Neamul Hasan, Abu Bakar Siddik, Mohammad Tanbir Habib, Damien M Slater, Ashlee M Earl, Colin J Worby, Kasrina Azad, S M Shamsuzzaman, Nusrat Noor Tanni, Raisa Tasnia Khan, Meherunnisa Moonmoon, Firdausi Qadri, Jason B Harris, Regina C LaRocque

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Abstract

We evaluated Klebsiella pneumoniae (Kp) gut carriage in healthy, unrelated adults and children living in separate households in Dhaka, Bangladesh. Average Kp prevalence in stool samples ranged from 61% in young children (15/25) to 81% in adults (21/26), with significantly higher abundance in adults (P = .03, t-test). Kp was also prevalent in household water (64%, 21/33) and standing water (85%, 23/27). The presence of Kp in household water was not strongly linked to stool Kp abundance among household members. Antimicrobial resistance was notable: 9% (6/69) of stool and 16% (7/44) of water isolates exhibited multidrug resistance. Carbapenem resistance was observed in 12% of stool isolates (8/69) and 14% of water isolates (6/44). These findings underscore the commonality of Kp in human and environmental reservoirs in Dhaka, Bangladesh, and highlight the emergence of drug-resistant Kp beyond healthcare settings.

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孟加拉国达卡粪便和水样本中抗碳青霉烯类肺炎克雷伯氏菌的高流行率。

我们对孟加拉国达卡不同家庭中健康、无血缘关系的成人和儿童的肺炎克雷伯氏菌（Kp）肠道携带情况进行了评估。粪便样本中 Kp 的平均感染率从幼儿（15/25）的 61% 到成人（21/26）的 81%，成人的感染率明显更高（P = .03，t 检验）。Kp 在家庭用水（64%，21/33）和积水（85%，23/27）中也很普遍。家庭用水中的 Kp 与家庭成员粪便中 Kp 的含量并无密切联系。抗菌药耐药性值得注意：9%（6/69）的粪便分离物和 16%（7/44）的水中分离物表现出多重耐药性。12% 的粪便分离物（8/69）和 14% 的水中分离物（6/44）对碳青霉烯类耐药。这些发现强调了孟加拉国达卡的人类和环境储库中 Kp 的普遍性，并凸显了耐药 Kp 在医疗环境之外的出现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.