Biological evaluation of ZrO₂ composites modified with different ceramics additives.

IF 4.5 3区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2024-12-01 Epub Date: 2024-11-04 DOI:10.1080/21691401.2024.2422870

Magdalena Ziąbka, Agnieszka Wojteczko, Barbara Zagrajczuk, Aleksandra Benko, Sebastian Komarek, Elżbieta Menaszek

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引用次数: 0

Abstract

In this work, zirconia (ZrO₂) composites modified with bioactive hydroxyapatite (HAp), hexagonal boron nitride (hBN), bioglass (BG), and bioglass with copper (BGCu) via the hydrothermal method were synthesized. The aim was to obtain highly bioactive and cytocompatible materials that could combine beneficial properties of inert and bioactive ceramics. Such materials could be applied as fillers for tooth extraction cavities, guaranteeing osseintegration without the need to introduce additional bone cements or other adhesives. It was proven that while all materials were favourable towards cells adhesion and growth, the HAp and BG-doped ones facilitated early adhesion, especially when compared to unmodified ZrO₂. Only the HAp-doped materials showed satisfactory bioactivity results, with a well-developed apatite layer forming on their surfaces. This study confirms that the Hap-doped ZrO₂ is suitable for treating bone defects.

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用不同陶瓷添加剂改性的 ZrO2 复合材料的生物学评价。

这项研究通过水热法合成了具有生物活性的羟基磷灰石（HAp）、六方氮化硼（hBN）、生物玻璃（BG）和含铜生物玻璃（BGCu）修饰的氧化锆（ZrO2）复合材料。目的是获得具有高度生物活性和细胞相容性的材料，这些材料可兼具惰性陶瓷和生物活性陶瓷的有益特性。这种材料可用作拔牙龋洞的填充物，保证骨整合，而无需引入额外的骨水泥或其他粘合剂。实验证明，虽然所有材料都有利于细胞的粘附和生长，但掺杂 HAp 和 BG 的材料更有利于细胞的早期粘附，尤其是与未改性的 ZrO2 相比。只有掺杂 HAp 的材料显示出令人满意的生物活性，其表面形成了发达的磷灰石层。这项研究证实，Hap 掺杂的 ZrO2 适合用于治疗骨缺损。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Artificial Cells, Nanomedicine, and Biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ENGINEERING, BIOMEDICAL

CiteScore

10.90

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： Artificial Cells, Nanomedicine and Biotechnology covers the frontiers of interdisciplinary research and application, combining artificial cells, nanotechnology, nanobiotechnology, biotechnology, molecular biology, bioencapsulation, novel carriers, stem cells and tissue engineering. Emphasis is on basic research, applied research, and clinical and industrial applications of the following topics:artificial cellsblood substitutes and oxygen therapeuticsnanotechnology, nanobiotecnology, nanomedicinetissue engineeringstem cellsbioencapsulationmicroencapsulation and nanoencapsulationmicroparticles and nanoparticlesliposomescell therapy and gene therapyenzyme therapydrug delivery systemsbiodegradable and biocompatible polymers for scaffolds and carriersbiosensorsimmobilized enzymes and their usesother biotechnological and nanobiotechnological approachesRapid progress in modern research cannot be carried out in isolation and is based on the combined use of the different novel approaches. The interdisciplinary research involving novel approaches, as discussed above, has revolutionized this field resulting in rapid developments. This journal serves to bring these different, modern and futuristic approaches together for the academic, clinical and industrial communities to allow for even greater developments of this highly interdisciplinary area.