Association of lamina cribrosa thickness and hippocampal volume in Alzheimer's disease patients.

IF 1 4区医学 Q4 NEUROSCIENCES

Arquivos de neuro-psiquiatria Pub Date : 2024-11-01 Epub Date: 2024-11-03 DOI:10.1055/s-0044-1791658

Ersin Kasım Ulusoy, Döndü Melek Ulusoy, Mehmet Fatih Göl, Ayşe Çiçek, Turgut Tursem Tokmak

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Abstract

Background: Alzheimer's disease (AD) is the most common cause of dementia and affects a large portion of the elderly population worldwide.

Objective: To analyze the relationship between lamina cribrosa thickness (LCT) and hippocampal volume in patients with AD and mild cognitive impairment (MCI).

Methods: The sample in the present study consisted of 20 recently diagnosed MCI patients, 20 recently diagnosed AD patients, and 20 matched healthy volunteers. Every patient underwent magnetic resonance imaging (MRI) scans. The VolBrain software (open-access platform for MRI brain analysis) was used to calculate the hippocampal volume. Optical coherence tomography was performed to measure the LCT. Analysis of variance and Pearson chi-squared tests were employed to assess the results.

Results: The lowest total hippocampal volume (p < 0.05) was in the AD group, which was 6.14 ± 0.66 mm³, while in the control group, it was 7.7 ± 9.65 mm³, and 6.69 ± 0.46 mm³ in the MCI group. In comparison to the rest of the groups, in the AD group, the LCT was the thinnest (202.17 ± 16.35 µm). As per the results of the study population as a whole, low hippocampal volume causes low LCT, which shows an important relationship (r: 0.41; p < 0.05).

Conclusion: The current findings present evidence of the relationship between hippocampal volume and LCT in patients with AD and MCI.

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阿尔茨海默病患者的颅骨板厚度与海马体积的关系

背景：阿尔茨海默病（AD）是最常见的痴呆症，影响着全球大部分老年人口：阿尔茨海默病（AD）是导致痴呆症的最常见原因，影响着全球大部分老年人口：目的：分析AD和轻度认知障碍（MCI）患者的颅骨板厚度（LCT）与海马体积之间的关系：本研究的样本包括 20 名新近确诊的 MCI 患者、20 名新近确诊的 AD 患者和 20 名匹配的健康志愿者。每位患者都接受了磁共振成像（MRI）扫描。使用 VolBrain 软件（开放式核磁共振成像脑分析平台）计算海马体积。光学相干断层扫描用于测量 LCT。结果采用方差分析和皮尔逊卡方检验进行评估：对照组海马总体积最低（p 3），为 7.7 ± 9.65 mm3，MCI 组为 6.69 ± 0.46 mm3。与其他组相比，AD 组的 LCT 最薄（202.17 ± 16.35 µm）。从整个研究人群的结果来看，海马体积低会导致 LCT 低，两者之间存在重要关系（r：0.41; p 结论目前的研究结果表明，AD 和 MCI 患者的海马体积与 LCT 之间存在关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivos de neuro-psiquiatria 医学-精神病学

CiteScore

2.10

自引率

7.10%

发文量

262

审稿时长

4-8 weeks

期刊介绍： Arquivos de Neuro-Psiquiatria is the official journal of the Brazilian Academy of Neurology. The mission of the journal is to provide neurologists, specialists and researchers in Neurology and related fields with open access to original articles (clinical and translational research), editorials, reviews, historical papers, neuroimages and letters about published manuscripts. It also publishes the consensus and guidelines on Neurology, as well as educational and scientific material from the different scientific departments of the Brazilian Academy of Neurology. The ultimate goals of the journal are to contribute to advance knowledge in the areas of Neurology and Neuroscience, and to provide valuable material for training and continuing education for neurologists and other health professionals working in the area. These goals might contribute to improving care for patients with neurological diseases. We aim to be the best Neuroscience journal in Latin America within the peer review system.