D-Penicillamine-Induced Stevens-Johnson Syndrome in a Patient with Gold Cyanide Intoxication: A Case Report.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-10-28 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S489028

Tanaporn Anuntrangsee, Kumutnart Chanprapaph, Wimolsiri Iamsumang

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Abstract

D-penicillamine is used as the mainstay of chelation therapy for Wilson's disease and for heavy metal intoxication. D-penicillamine itself has been noted to cause several systemic side effects as well as symptoms related to the skin. Common cutaneous side effects such as acute hypersensitivity reactions, elastic fiber abnormalities, and bullous diseases have been occasionally described. Herein, we report a case of a 23-year-old Thai female with gold intoxication who developed Stevens-Johnson syndrome (SJS) following the treatment of D-penicillamine. To our knowledge, D-penicillamine-induced SJS is exceptionally rare. To raise awareness of potentially fatal cutaneous adverse drug reaction triggered by D-penicillamine, published literature regarding SJS induced by this agent has also been reviewed. D-penicillamine should be regarded as a possible culprit in patients presenting with SJS following D-penicillamine administration and should be promptly discontinued.

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一名氰化金中毒患者的 D-青霉胺诱发史蒂文斯-约翰逊综合征：病例报告。

D-青霉胺是治疗威尔逊氏病和重金属中毒的主要螯合剂。人们注意到，D-青霉胺本身会引起多种全身性副作用以及与皮肤有关的症状。常见的皮肤副作用如急性超敏反应、弹力纤维异常和大疱性疾病也偶有描述。在此，我们报告了一例 23 岁的泰国女性金中毒患者在接受 D-青霉胺治疗后出现史蒂文斯-约翰逊综合征（SJS）的病例。据我们所知，D-青霉胺诱发的 SJS 异常罕见。为了提高人们对D-青霉胺可能引发致命皮肤药物不良反应的认识，我们还回顾了已发表的有关该药物诱发SJS的文献。服用 D-青霉胺后出现 SJS 的患者应将 D-青霉胺视为可能的罪魁祸首，并应立即停药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.