Metabolomics in the Diagnosis of Bacterial Infections

IF 3.2 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2024-11-01 DOI:10.1016/j.cca.2024.120020

Somayeh Ahmadi , Farzaneh Rafie Sedaghat , Mohammad Yousef Memar , Mina Yekani

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引用次数: 0

Abstract

One of the essential factors in the appropriate treatment of infections is accurate and timely laboratory diagnosis. The correct diagnosis of infections plays a vital role in determining desirable therapy and controlling the spread of pathogens. Traditional methods of infection diagnosis are limited by several factors such as insufficient sensitivity and specificity, being time-consuming and laborious, having a low ability to distinguish infection from non-infectious inflammatory conditions and a low potential to predict treatment outcomes. Therefore, it is necessary to find innovative strategies for detecting specific biomarkers in order to diagnose infections. The rapid advancement of metabolomics makes it possible to determine the pattern of metabolite changes in the both of pathogen and the host during an infection. Metabolomics is a method used to assess the levels and type of metabolites in an organism. Metabolites are of low-molecular-weight compounds produced as a result of metabolic processes and pathways within cells. Metabolomics provides valuable data to detect accurate biomarkers of specific biochemical features directly related to certain phenotypes or conditions. This study aimed to review the applications and progress of metabolomics as a biomarker for the diagnosis of bacterial infections.

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代谢组学在细菌感染诊断中的应用。

准确及时的实验室诊断是适当治疗感染的重要因素之一。正确的感染诊断对于确定理想的治疗方法和控制病原体的传播起着至关重要的作用。传统的感染诊断方法受到多种因素的限制，如灵敏度和特异性不足、费时费力、区分感染和非感染性炎症的能力较低、预测治疗结果的潜力较低等。因此，有必要找到检测特定生物标志物的创新策略，以诊断感染。代谢组学的快速发展使确定感染期间病原体和宿主体内代谢物的变化模式成为可能。代谢组学是一种用于评估生物体内代谢物水平和类型的方法。代谢物是细胞内代谢过程和途径产生的低分子量化合物。代谢组学提供了宝贵的数据，可准确检测与某些表型或状况直接相关的特定生化特征的生物标记物。本研究旨在回顾代谢组学作为诊断细菌感染的生物标志物的应用和进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.