Characterisation of pathogenic Leptospira in invasive raccoons (Procyon lotor) in northeast and southwest France.

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Epidemiology and Infection Pub Date : 2024-11-04 DOI:10.1017/S095026882400116X

Florence Ayral, Elena Harran, Christine Fournier-Chambrillon, Manon Gautrelet, Océane Tourniaire, Alexis Peutot, Karine Groud, Nathan Thenon, Pascal Fournier, Céline Richomme

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Abstract

Leptospirosis is a widespread zoonosis caused by bacteria of the genus Leptospira. Although crucial to mitigate the disease risk, basic epidemiological information is lacking, such as the identities of Leptospira maintenance hosts. The raccoon (Procyon lotor), an alien invasive species in France, could pose a public health risk if it carries pathogenic Leptospira. We investigated the rate and type (selective vs. unselective) of Leptospira carriage in the two main raccoon populations in France. Out of the 141 raccoons collected, seven (5%) tested quantitative PCR positive, targeting lfb1 gene, based on kidney, lung, and urine samples. Phylogenetic analysis revealed the presence of three different L. interrogans clusters. The results suggest that raccoons were more likely accidental hosts and made only a limited contribution to Leptospira maintenance.

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法国东北部和西南部入侵浣熊（Procyon lotor）中致病性钩端螺旋体的特征。

钩端螺旋体病是由钩端螺旋体属细菌引起的一种广泛的人畜共患疾病。尽管对降低疾病风险至关重要，但目前仍缺乏基本的流行病学信息，例如钩端螺旋体维持宿主的身份。浣熊（Procyon lotor）是法国的外来入侵物种，如果它携带致病性钩端螺旋体，就会对公共健康构成威胁。我们调查了法国两大浣熊种群中携带钩端螺旋体的比例和类型（选择性与非选择性）。在收集到的 141 只浣熊中，有 7 只（5%）在肾脏、肺部和尿液样本中检测到针对 lfb1 基因的定量 PCR 阳性。系统发育分析表明存在三个不同的 L. interrogans 集群。结果表明，浣熊更可能是意外宿主，对钩端螺旋体的维持作用有限。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epidemiology and Infection 医学-传染病学

CiteScore

4.10

自引率

2.40%

发文量

366

审稿时长

3-6 weeks

期刊介绍： Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.