Low handgrip strength as a marker of severity in the diagnostic criteria for cancer cachexia.

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2024-11-01 DOI:10.1016/j.clnesp.2024.10.162

Tatsuma Sakaguchi, Keisuke Maeda, Tomoko Takeuchi, Yuria Ishida, Ryoko Kato, Junko Ueshima, Akio Shimizu, Ayano Nagano, Koki Kawamura, Koji Amano, Naoharu Mori

{"title":"Low handgrip strength as a marker of severity in the diagnostic criteria for cancer cachexia.","authors":"Tatsuma Sakaguchi, Keisuke Maeda, Tomoko Takeuchi, Yuria Ishida, Ryoko Kato, Junko Ueshima, Akio Shimizu, Ayano Nagano, Koki Kawamura, Koji Amano, Naoharu Mori","doi":"10.1016/j.clnesp.2024.10.162","DOIUrl":null,"url":null,"abstract":"Background & aims: The diagnostic criteria for cachexia, as proposed by the Asian Working Group for Cachexia (AWGC), include weight loss, a low body mass index, and additional factors such as a low handgrip strength (HGS), anorexia, or elevated CRP levels. This study aimed to evaluate the significance of low HGS as a diagnostic criterion in patients with advanced cancer.Methods: This single-centre, retrospective cohort study was conducted between April 2019 and March 2023. Patients aged ≥18 years with malignant diseases were included. Patients without records on HGS were excluded. Low HGS was defined as a HGS <28 kg for men and <18 kg for women. The overall median survival time (MST) was analysed by univariate and multivariate analyses.Results: A total of 894 patients were analysed. Cachexia was prevalent in 74 %, though only 3.4 % were diagnosed based solely on low HGS. The MST in patients with cachexia was 122 days, and in those with low HGS was 73 days. The associations between low HGS and high mortality remained significant after adjusting for AWGC criteria, modified weight loss grading system, age, gender, performance status, calf circumferenceand fluid retention. The MST varied with the number of additional factors being met: 422 days for one criterion, 92 days for two, and 55 days for all three (p < 0.0001).Conclusion: This study supports that HGS serve as important prognostic tool in patients with various cancers.","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical nutrition ESPEN","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.clnesp.2024.10.162","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background & aims: The diagnostic criteria for cachexia, as proposed by the Asian Working Group for Cachexia (AWGC), include weight loss, a low body mass index, and additional factors such as a low handgrip strength (HGS), anorexia, or elevated CRP levels. This study aimed to evaluate the significance of low HGS as a diagnostic criterion in patients with advanced cancer.

Methods: This single-centre, retrospective cohort study was conducted between April 2019 and March 2023. Patients aged ≥18 years with malignant diseases were included. Patients without records on HGS were excluded. Low HGS was defined as a HGS <28 kg for men and <18 kg for women. The overall median survival time (MST) was analysed by univariate and multivariate analyses.

Results: A total of 894 patients were analysed. Cachexia was prevalent in 74 %, though only 3.4 % were diagnosed based solely on low HGS. The MST in patients with cachexia was 122 days, and in those with low HGS was 73 days. The associations between low HGS and high mortality remained significant after adjusting for AWGC criteria, modified weight loss grading system, age, gender, performance status, calf circumferenceand fluid retention. The MST varied with the number of additional factors being met: 422 days for one criterion, 92 days for two, and 55 days for all three (p < 0.0001).

Conclusion: This study supports that HGS serve as important prognostic tool in patients with various cancers.

查看原文本刊更多论文

在癌症恶病质诊断标准中，低握力是严重程度的标志。

背景与目的：亚洲恶病质工作组（AWGC）提出的恶病质诊断标准包括体重减轻、低体重指数以及其他因素，如低握力（HGS）、厌食或 CRP 水平升高。本研究旨在评估低 HGS 作为晚期癌症患者诊断标准的意义：这项单中心回顾性队列研究在 2019 年 4 月至 2023 年 3 月期间进行。研究纳入了年龄≥18 岁的恶性肿瘤患者。排除无 HGS 记录的患者。低 HGS 被定义为 HGS 结果：共分析了 894 名患者。74%的患者患有恶病质，但仅有 3.4% 的患者仅根据低 HGS 诊断为恶病质。恶病质患者的 MST 为 122 天，而低 HGS 患者的 MST 为 73 天。在对 AWGC 标准、改良体重减轻分级系统、年龄、性别、表现状态、小腿围度和液体潴留进行调整后，低 HGS 与高死亡率之间的关系仍然显著。MST随符合的附加因素数量而变化：符合一项标准为 422 天，符合两项标准为 92 天，符合所有三项标准为 55 天（p 结论）：本研究证实，HGS 是各种癌症患者预后的重要工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.