Transcutaneous Auricular Vagus Nerve Stimulation for Visually Induced Motion Sickness: An eLORETA Study.

IF 2.3 3区 医学 Q3 CLINICAL NEUROLOGY
Emmanuel Molefi, Ian McLoughlin, Ramaswamy Palaniappan
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Abstract

Transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive form of electrical brain stimulation, has shown potent therapeutic potential for a wide spectrum of conditions. How taVNS influences the characterization of motion sickness - a long mysterious syndrome with a polysymptomatic onset - remains unclear. Here, to examine taVNS-induced effects on brain function in response to motion-induced nausea, 64-channel electroencephalography (EEG) recordings from 42 healthy participants were analyzed; collected during nauseogenic visual stimulation concurrent with taVNS administration, in a crossover randomized sham-controlled study. Cortical neuronal generators were estimated from the obtained EEG using exact low-resolution brain electromagnetic tomography (eLORETA). While both sham and taVNS increased insula activation during electrical stimulation, compared to baseline, taVNS additionally augmented middle frontal gyrus neuronal activity. Following taVNS, brain regions including the supramarginal, parahippocampal, and precentral gyri were activated. Contrasting sham, taVNS markedly increased activity in the middle occipital gyrus during stimulation. A repeated-measures ANOVA showed that taVNS reduced motion sickness symptoms. This reduction in symptoms correlated with taVNS-induced neural activation. Our findings provide new insights into taVNS-induced brain changes, during and after nauseogenic stimuli exposure, including accompanying behavioral response. Together, these findings suggest that taVNS has promise as an effective neurostimulation tool for motion sickness management.

经皮耳廓迷走神经刺激治疗视觉诱发的晕动症:eLORETA 研究。
经皮耳廓迷走神经刺激疗法(taVNS)是一种非侵入性的脑电刺激疗法,对多种疾病具有强大的治疗潜力。晕动病是一种长期存在的神秘综合征,发病时会出现多种症状,taVNS 如何影响晕动病的特征描述仍不清楚。在这里,为了研究 taVNS 对运动诱发恶心的大脑功能的影响,我们分析了 42 名健康参与者的 64 通道脑电图(EEG)记录;这些记录是在一项交叉随机假对照研究中,在服用 taVNS 的同时进行恶心视觉刺激时收集的。利用精确低分辨率脑电磁层析成像(eLORETA)技术从获得的脑电图中估算皮层神经元发生器。与基线相比,假性和 taVNS 在电刺激过程中都会增加脑岛的激活,而 taVNS 还会增加额中回的神经元活动。进行 taVNS 后,包括边际上、海马旁和前脑回在内的脑区被激活。与假性相反,taVNS 在刺激过程中明显增加了枕叶中回的活动。重复测量方差分析显示,taVNS 可减轻晕动病症状。症状的减轻与 taVNS 诱导的神经激活有关。我们的研究结果为我们提供了关于taVNS诱导的大脑变化、恶心刺激暴露期间和之后的新见解,包括伴随的行为反应。这些研究结果表明,taVNS 有望成为一种有效的神经刺激工具,用于晕动病治疗。
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来源期刊
Brain Topography
Brain Topography 医学-临床神经学
CiteScore
4.70
自引率
7.40%
发文量
41
审稿时长
3 months
期刊介绍: Brain Topography publishes clinical and basic research on cognitive neuroscience and functional neurophysiology using the full range of imaging techniques including EEG, MEG, fMRI, TMS, diffusion imaging, spectroscopy, intracranial recordings, lesion studies, and related methods. Submissions combining multiple techniques are particularly encouraged, as well as reports of new and innovative methodologies.
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