Update on the structure and function of Candida albicans drug efflux protein, Cdr1

IF 2.4 3区生物学 Q3 GENETICS & HEREDITY

Fungal Genetics and Biology Pub Date : 2024-10-30 DOI:10.1016/j.fgb.2024.103938

Chibuike Ibe, Carolina H. Pohl

引用次数: 0

Abstract

Candida albicans is an important human pathogenic yeast, that can become resistant to commonly used antifungal agents, such as azoles. One mechanism of drug resistance is efflux via ATP binding cassette transporters, such as Cdr1. Several studies have investigated the structural organization, binding mechanisms, function and regulation of Cdr1. This review summarizes the findings on the structure and function of Cdr1 and highlights important aspects to consider in future research relating to multidrug ABC transporters.

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白色念珠菌药物外排蛋白 Cdr1 的最新结构和功能。

白色念珠菌是一种重要的人类致病酵母菌，可对常用的抗真菌剂（如唑类）产生耐药性。耐药性的一个机制是通过 ATP 结合盒转运体（如 Cdr1）外流。一些研究对 Cdr1 的结构组织、结合机制、功能和调控进行了调查。本综述总结了有关 Cdr1 结构和功能的研究结果，并强调了今后有关多药 ABC 转运体研究中需要考虑的重要方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fungal Genetics and Biology 生物-遗传学

CiteScore

6.20

自引率

3.30%

发文量

审稿时长

85 days

期刊介绍： Fungal Genetics and Biology, formerly known as Experimental Mycology, publishes experimental investigations of fungi and their traditional allies that relate structure and function to growth, reproduction, morphogenesis, and differentiation. This journal especially welcomes studies of gene organization and expression and of developmental processes at the cellular, subcellular, and molecular levels. The journal also includes suitable experimental inquiries into fungal cytology, biochemistry, physiology, genetics, and phylogeny. Fungal Genetics and Biology publishes basic research conducted by mycologists, cell biologists, biochemists, geneticists, and molecular biologists. Research Areas include: • Biochemistry • Cytology • Developmental biology • Evolutionary biology • Genetics • Molecular biology • Phylogeny • Physiology.