Enhanced Delta-gamma Phase Amplitude Coupling during Phasic REM Sleep in isolated REM Sleep Behavior Disorder.

IF 5.6 2区医学 Q1 Medicine

Sleep Pub Date : 2024-11-02 DOI:10.1093/sleep/zsae258

Tae-Gon Noh, Kang-Min Choi, Jin-Sun Jun, Jung-Won Shin, Jeong-Ick Byun, Jun-Sang Sunwoo, Ki-Young Jung

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Abstract

Study objectives: This study aims to analyze phase-amplitude coupling (PAC) patterns during rapid eye movement (REM) sleep in patients with isolated REM sleep behavior disorder (iRBD), compared with demography-matched healthy control (HC) participants.

Methods: At baseline, electroencephalogram data from 13 iRBD patients and 10 HCs during REM sleep were analyzed. During follow-up, 4 patients (converters) later converted to alpha-synucleinopathies. Phasic and tonic REM states were determined by eye movement in 3-second epochs. PAC was compared between the groups, and correlations with clinical indicators were investigated. Additionally, the contribution of each electrode to PAC components was assessed.

Results: Patients with iRBD exhibited increased delta (1-3 Hz)-gamma (30-50 Hz) PAC only during the phasic REM state, but not during the tonic state, compared to the HCs (p < 0.05). Elevated PAC in patients negatively correlated with the REM atonia index (p = 0.011) and olfactory function (p = 0.038). Increase PACs were predominent in the fronto-temporo-occipital regions (corrected p < 0.05). Furthermore, patients showed reduced gamma-amplitude contributions of the parietal region (corrected p < 0.05). This reduction exhibited a progressively decreasing trend from HC to non-converters, and further to converters (p for trend = 0.044).

Conclusions: Our findings suggest PAC patterns during REM sleep could provide pathophysiological insights for iRBD. The widespread increase of PAC and reduced gamma-amplitude contribution in the parietal region suggest PAC during phasic REM sleep as potential biomarkers for disease progression in iRBD.

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在孤立的快速眼动睡眠行为障碍患者的相位快速眼动睡眠中，Delta-gamma 相位振幅耦合增强。

研究目的本研究旨在分析孤立快速眼动睡眠行为障碍（iRBD）患者在快速眼动睡眠期间的相位-振幅耦合（PAC）模式，并与人口统计学匹配的健康对照组（HC）参与者进行比较：方法：分析了 13 名 iRBD 患者和 10 名 HC 在快速眼动睡眠期间的脑电图基线数据。在随访期间，4 名患者（转换者）后来转换为α-突触核蛋白病。相位和强直性快速动眼期状态是通过眼球运动在 3 秒内的时程来确定的。对各组间的 PAC 进行了比较，并研究了与临床指标的相关性。此外，还评估了每个电极对 PAC 成分的贡献：结果：与普通人相比，iRBD 患者仅在相位快速眼动状态下的 delta（1-3 Hz）-gamma（30-50 Hz）PAC 增加，而在强直状态下没有增加（p < 0.05）。患者的 PAC 升高与快速动眼期失张力指数（p = 0.011）和嗅觉功能（p = 0.038）呈负相关。PAC 的增加主要发生在额颞枕区（校正后 p <0.05）。此外，患者顶叶区的伽马振幅贡献减少（校正后 p < 0.05）。这种减少呈现出从HC到非转换者，再到转换者逐渐减少的趋势（趋势p = 0.044）：我们的研究结果表明，快速动眼期睡眠中的 PAC 模式可为 iRBD 提供病理生理学启示。顶叶区 PAC 的广泛增加和伽马振幅贡献的减少表明，相位快速眼动睡眠期间的 PAC 是 iRBD 疾病进展的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Medicine-Neurology (clinical)

CiteScore

8.70

自引率

10.70%

发文量

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