Association between slow wave sleep and blood pressure in insomnia.

IF 5.6 2区医学 Q1 Medicine

Sleep Pub Date : 2024-11-02 DOI:10.1093/sleep/zsae257

Rong Ren, Ye Zhang, Xujun Feng, Yuan Shi, Yuru Nie, Yongming Wang, Virend K Somers, Naima Covassin, Xiangdong Tang

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引用次数: 0

Abstract

Study objectives: The majority of patients with insomnia exhibit abnormal sleep in objective testing (e.g., decreased sleep duration, decreased slow wave sleep (SWS). Previous studies have suggested that some of these objective measures of poor sleep, such as decreased sleep duration, are associated with a higher risk of hypertension in insomnia. We examined the relationship between SWS and morning and evening blood pressure (BP) levels in patients with clinically diagnosed insomnia.

Methods: A total of 229 normal sleepers and 1378 insomnia patients were included in this study. Insomnia was defined based on standard diagnostic criteria with symptoms lasting ≥6 months. All subjects underwent in-laboratory polysomnography. Patients were classified into quartiles of percent SWS. Evening and morning hypertension were defined using BP measurements taken in the evening before and in the morning after polysomnography, respectively. Multivariable logistic regression models were used to assess the relationship between insomnia, SWS and hypertension.

Results: Insomniacs with <3.5% SWS (OR 3.27, 95% CI 1.31-7.66) and those with 3.5-10.2% SWS (OR 2.38, 95% CI 1.28-5.91) had significantly greater odds of morning hypertension compared to normal sleepers. No associations were seen in insomnia with 10.2-15.8% SWS and with >15.8% SWS. Significant effect modifications by sex (p=0.043) were found, as decreased SWS was associated with morning hypertension only in men. Odds of evening hypertension were not significantly associated with SWS.

Conclusion: Decreased SWS is associated with morning hypertension in a dose-dependent manner in insomnia, especially in men.

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失眠症患者慢波睡眠与血压之间的关系

研究目的：大多数失眠症患者在客观测试中表现出睡眠异常（如睡眠时间缩短、慢波睡眠（SWS）减少）。以往的研究表明，睡眠质量差的一些客观指标（如睡眠时间缩短）与失眠症患者罹患高血压的风险较高有关。我们研究了临床诊断为失眠症患者的慢波睡眠与早晚血压（BP）水平之间的关系：本研究共纳入了 229 名正常睡眠者和 1378 名失眠患者。失眠的定义基于标准诊断标准，症状持续时间≥6个月。所有受试者均接受了实验室多导睡眠图检查。患者被划分为 SWS 百分比四分位数。晚间高血压和早晨高血压的定义分别采用多导睡眠图检查前和检查后测量的血压值。采用多变量逻辑回归模型评估失眠、SWS 和高血压之间的关系：失眠者中有 15.8% 的人患有 SWS。结果显示：失眠者的 SWS 为 15.8%，性别对其影响有显著改变（p=0.043），只有男性的 SWS 减少与晨间高血压相关。晚间高血压的几率与SWS无明显关系：结论：失眠症患者，尤其是男性，SWS下降与晨间高血压呈剂量依赖关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Medicine-Neurology (clinical)

CiteScore

8.70

自引率

10.70%

发文量

期刊介绍： SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.