Retrospective cumulative dietary risk assessment of craniofacial alterations by residues of pesticides

IF 3.3 4区 医学 Q2 REPRODUCTIVE BIOLOGY
Luc Mohimont , Chris Anagnostopoulos , Maria Anastassiadou , Anna Federica Castoldi , Adeline Cavelier , Tamara Coja , Peter Craig , Federica Crivellente , Bruno Dujardin , Andy Hart , Wim Hooghe , Samira Jarrah , Kyriaki Machera , Elena Menegola , Francesca Metruccio , Christian Sieke
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Abstract

In 2022, the European Food Safety Authority (EFSA) conducted a dietary cumulative risk assessment for active substances of plant protection products on two types of craniofacial alterations: 1) craniofacial alterations due to abnormal skeletal development and 2) head soft tissue alterations and brain neural tube defects. These effects were selected based on developmental biology knowledge and a hypothetical teratogenic process. Cumulative risk assessment was conducted for 14 European populations of women in childbearing age. The dietary cumulative exposure was determined using individual consumption data collected under national food consumption surveys, and the calculations were based on occurrence data collected by Member States under their official monitoring programmes. A rigorous uncertainty analysis was performed using expert knowledge elicitation. Considering all sources of uncertainty, their dependencies, and differences between populations, it was concluded that the total margin of exposure (MOET) resulting from cumulative exposure to residues of pesticides is above 100 for both types of craniofacial alterations and therefore the threshold for regulatory consideration is not exceeded. For the head soft tissue alterations and brain neural tube defects the MOET was even above 500 while for the alterations due to abnormal skeletal development, it was found about as likely as not that the MOET is above 500 in most populations. These results need to be interpreted in the light of the conservatism of the hazard assessment methodology. This review is a summary of the EFSA report on a retrospective cumulative dietary risk assessment of craniofacial alterations by residues of pesticides published in 2022.
对农药残留导致颅面改变的累积膳食风险进行回顾性评估。
2022 年,欧洲食品安全局(EFSA)对两种类型的颅面改变进行了植物保护产品活性物质的膳食累积风险评估:1)骨骼发育异常导致的颅面改变;2)头部软组织改变和脑神经管缺陷。这些影响是根据发育生物学知识和假设的致畸过程选定的。对 14 个欧洲育龄妇女群体进行了累积风险评估。膳食累积暴露量是根据国家食品消费调查中收集的个人消费数据确定的,而计算则是基于成员国在其官方监测计划中收集的发生数据。采用专家知识征询法进行了严格的不确定性分析。考虑到所有不确定性来源、它们之间的依赖关系以及不同人群之间的差异,得出结论认为,对于两种类型的颅颌面改变而言,农药残留累积暴露所产生的总暴露阈值1 (MOET)均高于 100,因此没有超出监管考虑的阈值。对于头部软组织改变和脑神经管缺陷,MOET 甚至高于 500,而对于骨骼发育异常引起的改变,大多数人群的 MOET 都高于 500。需要根据危害评估方法的保守性来解释这些结果。本综述是欧洲食物安全局于 2022 年发布的关于农药残留导致颅颌面改变的回顾性累积膳食风险评估报告的摘要。
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来源期刊
Reproductive toxicology
Reproductive toxicology 生物-毒理学
CiteScore
6.50
自引率
3.00%
发文量
131
审稿时长
45 days
期刊介绍: Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.
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