The association between the triglyceride-glucose index and serum anti-aging protein α- Klotho: a population-based study.

IF 3.4 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Yan Zhang, Kexin Song, Zhuhua Yao
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引用次数: 0

Abstract

Background: Both anti-aging protein α-Klotho and the triglyceride-glucose (TyG) index hold predictive value for the incidence, progression, and outcomes of cardiovascular disease, diabetes and many other diseases. However, their relationship remains unclear.

Methods: We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2016. Weighted multivariate linear regression models and subgroup analysis were constructed to assess the association between TyG index and α-Klotho levels. Nonlinear correlations were explored using restricted cubic splines (RCS), generalized additive models (GAM) and smooth curve fitting. Segmented regression model was conducted to explore potential threshold effects and identify the inflection point.

Results: A total of 2568 participants satisfied the predetermined criteria were enrolled in the final analysis. After fully adjusting for covariates, TyG index was shown to be markedly negatively correlated with α-Klotho [β=-74.07, 95%CI (-100.29,-47.85), p < 0.001]. Gender was significantly correlated with this negative connection according to subgroup analysis and interaction testing (p for interaction < 0.05).Additionally, we discovered a linear association between TyG index and α-Klotho in all participants (p for nonlinear = 0.761), while non-linear association in female (p for nonlinear = 0.016).The analysis of threshold effect in the female participants found that the inflection point of TyG index was 8.01, exceed which the level of α-Klotho decreased significantly with increasing TyG index[β=-151.72, 95%CI (-201.93, -101.50), p < 0.001].

Conclusion: Our findings demonstrate a negative association between TyG index and α-Klotho levels, with the effect being more pronounced in females. TyG index may serve as an early indicator of individuals with low α-Klotho levels, especially among females. These findings highlight the need for gender-specific considerations in clinical interventions to improve public health. Further research is needed to clarify the causal direction of this association.

甘油三酯-葡萄糖指数与血清抗衰老蛋白 α- Klotho 之间的关联:一项基于人群的研究。
背景:抗衰老蛋白α-Klotho和甘油三酯-葡萄糖(TyG)指数对心血管疾病、糖尿病和许多其他疾病的发生、发展和预后都具有预测价值。然而,它们之间的关系仍不明确:我们利用 2007-2016 年美国国家健康与营养调查(NHANES)的数据进行了横断面分析。我们构建了加权多变量线性回归模型并进行了亚组分析,以评估TyG指数与α-Klotho水平之间的关系。利用受限立方样条(RCS)、广义加法模型(GAM)和平滑曲线拟合探讨了非线性相关性。为了探索潜在的阈值效应并确定拐点,还采用了分段回归模型:共有 2568 名符合预定标准的参与者参与了最终分析。完全调整协变量后,TyG指数与α-Klotho呈显著负相关[β=-74.07,95%CI(-100.29,-47.85),p 结论:我们的研究结果表明,TyG指数与α-Klotho呈显著负相关:我们的研究结果表明,TyG指数与α-Klotho水平呈负相关,女性的影响更为明显。TyG指数可作为α-Klotho水平低者的早期指标,尤其是女性。这些发现凸显了在临床干预中考虑性别差异以改善公众健康的必要性。要明确这种关联的因果方向,还需要进一步的研究。
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来源期刊
Diabetology & Metabolic Syndrome
Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-
CiteScore
6.20
自引率
0.00%
发文量
170
审稿时长
7.5 months
期刊介绍: Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.
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