The m6A-YTH regulatory system in plants: A status

IF 8.3 2区 生物学 Q1 PLANT SCIENCES
Peter Brodersen , Laura Arribas-Hernández
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引用次数: 0

Abstract

Plants use mRNA methylation to regulate gene expression. As in other eukaryotes, the only abundant methylated nucleotide in plant mRNA bodies is N6-methyladenosine (m6A). The conserved core components of m6A-based genetic control are a multi-subunit nuclear methyltransferase, and a set of nuclear and cytoplasmic RNA-binding proteins consisting of an m6A recognition module, the YT521-B homology (YTH) domain, and long intrinsically disordered regions (IDRs). In plants, this system is essential for growth during embryonic and post-embryonic development, but emerging evidence also points to key functions in plant-virus interactions and stimulus-dependent gene regulation. Cytoplasmic YTH-domain proteins are particularly important for these functions, and recent progress has identified two elements of the underlying molecular mechanisms: IDR-mediated phase separation and conserved short linear motifs mediating interactions with other key mRNA-binding proteins.
植物中的 m6A-YTH 调节系统:现状。
植物利用 mRNA 甲基化来调节基因表达。与其他真核生物一样,植物 mRNA 体内唯一丰富的甲基化核苷酸是 N6-甲基腺苷(m6A)。基于 m6A 的基因控制的保守核心成分是一个多亚基核甲基转移酶,以及一组由 m6A 识别模块、YT521-B 同源(YTH)结构域和长内在无序区(IDR)组成的核和细胞质 RNA 结合蛋白。在植物的胚胎和胚后发育过程中,该系统对生长至关重要,但新出现的证据也表明,它在植物与病毒的相互作用和依赖刺激的基因调控中也发挥着关键作用。细胞质 YTH-结构域蛋白对这些功能尤为重要,最近的研究进展已经确定了潜在分子机制的两个要素:最近的进展已经确定了潜在分子机制的两个要素:IDR 介导的相分离和介导与其他关键 mRNA 结合蛋白相互作用的保守短线性基团。
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来源期刊
Current opinion in plant biology
Current opinion in plant biology 生物-植物科学
CiteScore
16.30
自引率
3.20%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.
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