Acute tubulointerstitial nephritis associated with infliximab therapy in a patient with Crohn's disease: a case report.

IF 1 Q4 UROLOGY & NEPHROLOGY

CEN Case Reports Pub Date : 2024-11-02 DOI:10.1007/s13730-024-00943-6

Naif Alghamdi, Fahad Alshehri, Sultan Alhazza, Fahad Bhutto, Azhari Alhassan, Mohammed Kechrid, Dhafer Alshehri, Kadi Alshammari, Talal Assiri, Ohoud Assiri, Emad Darewsh, Mohammed Ali, Ruba Qadri, Yasser Alahmadi

引用次数: 0

Abstract

We report the case of a 39-year-old man who presented with a history of generalized fatigue, nausea, subjective fever with rigors, and renal dysfunction after receiving infliximab (IFX) therapy for Crohn's disease. A renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After other causes of acute kidney injury were excluded, steroid therapy was initiated, his fever subsided, and kidney function improved. From this case report, infliximab could be a rare cause of elevated kidney function and that it should be not considered a completely safe treatment or disregarded as potential cause of ATIN.

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一名克罗恩病患者因英夫利西单抗治疗引发的急性肾小管间质性肾炎：病例报告。

我们报告了一例 39 岁男子的病例，他在接受英夫利昔单抗（IFX）治疗克罗恩病后出现全身乏力、恶心、主观发热伴全身僵硬和肾功能障碍。肾活检显示患有急性肾小管间质性肾炎（ATIN）。在排除了急性肾损伤的其他病因后，开始使用类固醇治疗，他的烧退了，肾功能也有所改善。从该病例报告中可以看出，英夫利昔单抗可能是导致肾功能升高的一个罕见原因，因此不应将其视为一种完全安全的治疗方法，也不应将其视为导致ATIN的潜在原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CEN Case Reports UROLOGY & NEPHROLOGY-

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： Clinical and Experimental Nephrology (CEN) Case Reports is a peer-reviewed online-only journal, officially published biannually by the Japanese Society of Nephrology (JSN). The journal publishes original case reports in nephrology and related areas. The purpose of CEN Case Reports is to provide clinicians and researchers with a forum in which to disseminate their personal experience to a wide readership and to review interesting cases encountered by colleagues all over the world, from whom contributions are welcomed.