Sex-specific association between platelet content and bone mineral density in adults: a cross-sectional study.

IF 2.2 3区 医学 Q2 ORTHOPEDICS
Yucheng Zhang, Bofan Zhao, Zhendong Huang, Juan Xie, Xinli Zhou, Chanyang Fan, Meng Chen, Lixiang Yan, Zhexin Shi
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引用次数: 0

Abstract

Background: Osteoporosis (OP) is a complex skeletal disorder characterized by reduced bone mass, microarchitectural deterioration of bone tissue, and increased susceptibility to fractures. Bone mineral density (BMD), as the best indicator of bone mineral content per unit area of bone, is one of the key diagnostic factors for OP. Platelets (PLT), serving as important immune cells and components of the coagulation system, have been demonstrated to be associated with bone formation, resorption, and remodeling processes. However, no research has established the relationship between BMD and platelet count (PC) in the American population thus far. This study aims to investigate the correlation between BMD and PC among the American population, and to appraise the effects of additional risk factors on this association.

Methods: This investigation examined the relationship between BMD and PC by analyzing data from the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2018. A weighted multivariate logistic regression analysis was employed to assess this correlation. Additionally, subgroup and smooth curve analyses were conducted to delve deeper into the BMD-PC relationship and to identify other potential determinants of PC.

Results: This study reveals a significant negative correlation between BMD and PC in the American adult population (β=-15.05, 95% CI: -22.07 to -8.03, p < 0.0001). Subgroup analysis highlights notable differences in this correlation between genders and various racial groups. Smooth curve fitting and generalized additive models were applied to further explore the relationship between BMD and PC, considering the influence of multiple factors.

Conclusion: The present study investigated the correlation between BMD and PC in adults, with a particular focus on the potential risk factors for thrombocytopenia. This negative correlation was found to be markedly pronounced in males, an association not observed in females. Additionally, a potential inverse relationship between BMD and hemoglobin (HGB) levels was identified. Consequently, for individuals with elevated bone mass or osteoporosis (OP), we advocate for routine complete blood count monitoring to identify hematological irregularities. Considering the significant variations by sex, age, and race, special vigilance is advised for changes in PC among non-Hispanic white males under the age of 55.

成人血小板含量与骨矿物质密度之间的性别差异:一项横断面研究。
背景:骨质疏松症(Osteoporosis,OP)是一种复杂的骨骼疾病,其特征是骨量减少、骨组织微结构退化以及骨折易感性增加。骨矿物质密度(BMD)是单位面积骨骼中骨矿物质含量的最佳指标,是诊断骨质疏松症的关键因素之一。血小板(PLT)作为重要的免疫细胞和凝血系统的组成部分,已被证实与骨形成、吸收和重塑过程有关。然而,迄今为止还没有研究证实美国人的 BMD 与血小板计数(PC)之间的关系。本研究旨在调查美国人群中 BMD 与 PC 之间的相关性,并评估其他风险因素对这种相关性的影响:本研究通过分析 2011 年至 2018 年间美国国家健康与营养调查(NHANES)的数据,研究了 BMD 与 PC 之间的关系。采用加权多变量逻辑回归分析来评估这种相关性。此外,还进行了亚组和平滑曲线分析,以深入研究 BMD 与 PC 的关系,并确定 PC 的其他潜在决定因素:本研究揭示了美国成年人群中 BMD 与 PC 之间的显著负相关关系(β=-15.05,95% CI:-22.07 至 -8.03,p 结论:本研究调查了美国成年人群中 BMD 与 PC 之间的相关性:本研究调查了成人 BMD 与 PC 之间的相关性,尤其关注血小板减少症的潜在风险因素。研究发现,这种负相关性在男性中非常明显,而在女性中没有观察到这种关联。此外,还发现 BMD 与血红蛋白 (HGB) 水平之间存在潜在的反比关系。因此,对于骨量升高或骨质疏松症(OP)患者,我们主张进行常规全血细胞计数监测,以识别血液异常。考虑到不同性别、年龄和种族的显著差异,建议对 55 岁以下非西班牙裔白人男性的 PC 变化保持特别警惕。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Musculoskeletal Disorders
BMC Musculoskeletal Disorders 医学-风湿病学
CiteScore
3.80
自引率
8.70%
发文量
1017
审稿时长
3-6 weeks
期刊介绍: BMC Musculoskeletal Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of musculoskeletal disorders, as well as related molecular genetics, pathophysiology, and epidemiology. The scope of the Journal covers research into rheumatic diseases where the primary focus relates specifically to a component(s) of the musculoskeletal system.
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