Advancements in programmed cell death research in antitumor therapy: a comprehensive overview.

IF 6.1 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Shuxin Wei, Chuangye Han, Shutian Mo, Hailian Huang, Xiaoling Luo
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引用次数: 0

Abstract

Cell death is a normal physiological process within cells that involves multiple pathways, such as normal DNA damage, cell cycle arrest, and programmed cell death (PCD). Cell death has been a hot spot of research in tumor-related fields, especially programmed cell death, which is a key form of cell death and is classified into different types according to the mechanism of occurrence, such as apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, and disulfidptosis. Given the important role of PCD in maintaining tissue homeostasis and inhibiting tumorigenesis and development, more and more basic and clinical studies are devoted to revealing its potential application in anti-tumor strategies. The purpose of this review is to systematically review the regulatory mechanisms of PCD and to summarize the latest research progress of anti-tumor treatment strategies based on PCD.

抗肿瘤治疗中程序性细胞死亡研究的进展:全面概述。
细胞死亡是细胞内的正常生理过程,涉及多种途径,如正常的DNA损伤、细胞周期停滞和程序性细胞死亡(PCD)。细胞死亡一直是肿瘤相关领域的研究热点,尤其是程序性细胞死亡。程序性细胞死亡是细胞死亡的一种重要形式,根据发生机制可分为凋亡、自噬、坏死、热凋亡、铁凋亡和二硫化碳凋亡等不同类型。鉴于 PCD 在维持组织稳态、抑制肿瘤发生和发展方面的重要作用,越来越多的基础和临床研究致力于揭示其在抗肿瘤策略中的潜在应用。本综述旨在系统回顾 PCD 的调控机制,并总结基于 PCD 的抗肿瘤治疗策略的最新研究进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Apoptosis
Apoptosis 生物-生化与分子生物学
CiteScore
9.10
自引率
4.20%
发文量
85
审稿时长
1 months
期刊介绍: Apoptosis, a monthly international peer-reviewed journal, focuses on the rapid publication of innovative investigations into programmed cell death. The journal aims to stimulate research on the mechanisms and role of apoptosis in various human diseases, such as cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis, and aging. The Editor-In-Chief acknowledges the importance of advancing clinical therapies for apoptosis-related diseases. Apoptosis considers Original Articles, Reviews, Short Communications, Letters to the Editor, and Book Reviews for publication.
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