Similarities and differences between chronic primary pain and depression in brain activities: Evidence from resting-state microstates and auditory Oddball task

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2024-10-30 DOI:10.1016/j.bbr.2024.115319

Lele You , Banghua Yang , Xi Lu , Aolei Yang , Yonghuai Zhang , Xiaoying Bi , Shu Zhou

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引用次数: 0

Abstract

Background

In 2019, the International Association for the Study of Pain introduced the concept of 'chronic primary pain (CPP)', characterized by persistent non-organic pain with emotional and functional abnormalities. Underdiagnosed and linked to depression, CPP has poorly understood neural characteristics. Electroencephalogram (EEG) microstates enable detailed examination of brain network dynamics at the millisecond level. Incorporating task-related EEG features offers a comprehensive neurophysiological signature of brain dysfunction, facilitating exploration of potential neural mechanisms.

Methods

This study employed resting-state and task-related auditory Oddball EEG paradigm to evaluate 20 healthy controls, 20 patients with depression, and 20 patients with CPP. An 8-minute recording of resting-state EEG was conducted to identify four typical microstates (A-D). Additionally, power spectral density (PSD) features were examined during an auditory Oddball paradigm.

Results

Both CPP and Major Depressive Disorder (MDD) patients exhibited reduced occurrence rate and transition probabilities of other microstates to microstate C during resting-state EEG. Furthermore, more pronounced increase in Gamma PSD was observed in the occipital region of CPP during the Oddball task. In CPP, both resting-state microstate C and task-related Gamma PSD correlated with pain and emotional indicators. Notably, microstate C occurrence positively correlated with occipital Gamma PSD in MDD.

Conclusion

Conclusively, both CPP and MDD display dynamic abnormalities within the salient network, closely associated with pain and depressive symptoms in CPP. Unlike MDD, CPPs' dynamic network changes appear unrelated to perceptual integration function, indicating differing microstate functional impacts. Combining resting-state microstates and Oddball tasks may offer a promising avenue for identifying potential biomarkers in objectively assessing chronic primary pain.

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慢性原发性疼痛与抑郁症大脑活动的异同：静息态微观状态和听觉怪球任务的证据。

背景：2019 年，国际疼痛研究协会提出了 "慢性原发性疼痛 (CPP) "的概念，其特点是持续性非器质性疼痛伴有情绪和功能异常。CPP 诊断不足并与抑郁有关，其神经特征鲜为人知。脑电图（EEG）微状态可在毫秒级详细检查大脑网络动态。结合与任务相关的脑电图特征可提供大脑功能障碍的综合神经生理学特征，有助于探索潜在的神经机制：本研究采用静息态和任务相关听觉怪球脑电图范式对 20 名健康对照组、20 名抑郁症患者和 20 名 CPP 患者进行了评估。对静息态脑电图进行 8 分钟记录，以确定四种典型的微状态（A-D）。此外，还在听觉怪球范式中检查了功率谱密度（PSD）特征：结果：CPP 和重度抑郁障碍（MDD）患者在静息脑电图中均表现出其他微态向微态 C 的发生率和转换概率降低。此外，在进行怪球任务时，在 CPP 的枕叶区观察到更明显的伽马 PSD 增加。在 CPP 中，静息态微态 C 和任务相关伽马 PSD 都与疼痛和情绪指标相关。值得注意的是，在 MDD 中，微状态 C 的发生与枕部伽马 PSD 呈正相关：结论：CPP 和 MDD 的突出网络均显示出动态异常，这与 CPP 的疼痛和抑郁症状密切相关。与 MDD 不同的是，CPPs 的动态网络变化似乎与知觉整合功能无关，这表明微状态功能影响有所不同。将静息态微观状态与怪球任务相结合，可能会为确定客观评估慢性原发性疼痛的潜在生物标记物提供一条很有前景的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.