Survival rate changes in children with congenital diaphragmatic hernia over the past three decades: a nationwide, population-based prospective nested case-control study.

IF 1.5 3区医学 Q2 PEDIATRICS

Pediatric Surgery International Pub Date : 2024-11-01 DOI:10.1007/s00383-024-05860-4

B Kutasy, C M Burgos

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引用次数: 0

Abstract

Purpose: The survival rate (SR) for neonates born with congenital diaphragmatic hernia (CDH) remains high. Our aim was to investigate the change in SR in children with CDH over the past decades.

Methods: The study was a nationwide, population-based prospective nested case-control study within a cohort of newborn children who was born in Sweden during the observational period from 1st January 1982 to 31st December 2015.

Results: In the study period, 4654 (99.6%) control children and 684 children with CDH (70.4%, p < 0.001) were with a survival of 2 years of age. Any patients who were born with CDH had a overall 5.8 times higher chance for not surviving 2 years of age than children without CDH. The SR improved significantly in CDH in the past 3 decades. Significantly higher number of patients were prematurely born in the CDH group than in the controls (23.3 vs 6.1%, p < 0.001). The SR of premature and non-premature born CDH patients has increased significantly over the past 3 decades.

Conclusion: The SR of CDH patients were significantly increased in the past 3 decades. The 2-year survival remains 5.8 times higher than those who were not born with CDH. These changes were mainly attributed to the improved SR of premature and non-premature born CDH patients.

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过去三十年先天性膈疝患儿存活率的变化：一项全国性、基于人群的前瞻性巢式病例对照研究。

目的：患有先天性膈疝（CDH）的新生儿存活率（SR）仍然很高。我们的目的是调查过去几十年来 CDH 患儿存活率的变化情况：该研究是一项全国性、基于人口的前瞻性巢式病例对照研究，研究对象是1982年1月1日至2015年12月31日期间在瑞典出生的新生儿队列：在研究期间，4654名（99.6%）对照组儿童和684名CDH儿童（70.4%，P 结论：CDH患者的SR显著高于对照组儿童：CDH患者的SR在过去30年中明显增加。2年存活率仍比非 CDH 患儿高出 5.8 倍。这些变化主要归因于早产和非早产 CDH 患者的 SR 有所提高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Surgery International 医学-外科

CiteScore

3.00

自引率

5.60%

发文量

215

审稿时长

3-6 weeks

期刊介绍： Pediatric Surgery International is a journal devoted to the publication of new and important information from the entire spectrum of pediatric surgery. The major purpose of the journal is to promote postgraduate training and further education in the surgery of infants and children. The contents will include articles in clinical and experimental surgery, as well as related fields. One section of each issue is devoted to a special topic, with invited contributions from recognized authorities. Other sections will include: -Review articles- Original articles- Technical innovations- Letters to the editor