Burden of Current Insulin Therapy and Expectations for Future Insulin Therapy: Results from INBEING, a Web-Based Survey in Japan.

IF 3.8 3区医学 Q2 Medicine

Diabetes Therapy Pub Date : 2024-12-01 Epub Date: 2024-11-01 DOI:10.1007/s13300-024-01664-w

Yasuaki Hayashino, Satoshi Tsuboi, Yuiko Yamamoto, Hitoshi Ishii

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引用次数: 0

Abstract

Introduction: This survey assessed the perspectives of physicians, people with diabetes (PWD), and caregivers in Japan regarding initiation barriers and treatment burden associated with insulin therapy, and expectations for new insulin therapies.

Methods: An online survey, conducted May-June 2023, was completed by physicians (n = 411), PWD (type 1 diabetes, n = 108; type 2 diabetes [T2D]: insulin-naive, n = 114; insulin-treated, n = 108), and caregivers (family members, n = 107; nurses, n = 117; care workers, n = 104). Agreement with statements regarding initiation barriers, current feelings, and burden of insulin therapy was assessed. Physicians' views on ideal glycated hemoglobin (HbA_1c) levels and actual levels in PWD at insulin initiation were captured.

Results: Most PWD agreed with the statements "I don't want to be bothered with doing injections" (77.8-92.1%) and "I don't want to inject myself for the rest of my life" (78.7-91.2%). Physicians also considered these factors to be of high importance for PWD; however, physician and PWD (insulin-naive T2D) responses were significantly different for 11 statements. The greatest underestimation by physicians was for the statement "my family will be worried" (41.8% vs. 66.7%), whereas social factors (e.g., "my friendships may suffer," "if I take insulin I will be discriminated against") were overestimated by physicians (49.1% vs. 33.3% and 46.5% vs. 24.6%, respectively). Although > 70% of physicians considered HbA_1c < 9.0% (< 75 mmol/mol) ideal for insulin initiation, only ~ 30% of PWD started insulin at HbA_1c < 9.0% (< 75 mmol/mol). Nurses rated the burden of assisting with insulin injections significantly lower than family members or care workers. Respondents agreed the need for less frequent injections and improved glycemic control were important attributes expected from future insulin therapies.

Conclusion: Differences in perceptions between physicians and PWD in Japan regarding insulin therapy persist, but this gap may be narrowing. Both groups agreed that future insulin therapies should be simpler and provide better glycemic control.

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当前胰岛素治疗的负担和对未来胰岛素治疗的期望：日本网络调查 INBEING 的结果。

导言：这项调查评估了日本医生、糖尿病患者（PWD）和护理人员对与胰岛素治疗相关的起始障碍和治疗负担的看法，以及对新胰岛素疗法的期望：医生（n = 411）、糖尿病患者（1 型糖尿病，n = 108；2 型糖尿病 [T2D]：胰岛素免疫，n = 114；胰岛素治疗，n = 108）和护理人员（家庭成员，n = 107；护士，n = 117；护理人员，n = 104）完成了一项于 2023 年 5 月至 6 月进行的在线调查。评估了对有关胰岛素治疗的起始障碍、当前感受和负担的陈述的同意程度。此外，还了解了医生对残疾人理想糖化血红蛋白（HbA1c）水平和开始使用胰岛素时的实际水平的看法：结果：大多数残疾人同意 "我不想被注射所困扰"（77.8%-92.1%）和 "我不想一辈子注射"（78.7%-91.2%）的说法。医生也认为这些因素对残疾人非常重要；然而，医生和残疾人（胰岛素免疫性 T2D）对 11 项陈述的回答有显著差异。医生最低估的是 "我的家人会担心"（41.8% 对 66.7%），而社会因素（如 "我的友谊可能会受到影响"、"如果我服用胰岛素，我会受到歧视"）则被医生高估了（分别为 49.1% 对 33.3% 和 46.5% 对 24.6%）。尽管超过 70% 的医生认为 HbA1c 1c 结论：在日本，医生和残疾人对胰岛素治疗的认识仍然存在差异，但这种差距可能正在缩小。两组人都认为，未来的胰岛素疗法应该更简单，并提供更好的血糖控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes Therapy Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.90

自引率

7.90%

发文量

130

审稿时长

6 weeks

期刊介绍： Diabetes Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all areas of diabetes. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Diabetes Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.