Efficacy and safety of topical spironolactone versus topical dapsone in the treatment of acne vulgaris

IF 1.8 4区 医学 Q3 DERMATOLOGY
Khaled Gharib, Mai Samir, Gehad Mohamed, Mahmoud A. Rageh
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Abstract

Acne vulgaris is a common skin disease that greatly impacts the quality of life of affected individuals. Several treatment modalities are available for acne, with variable degrees of success. Our aim was to compare the safety and efficacy of topical spironolactone 5% gel and topical dapsone 5% gel as treatment modalities for acne vulgaris. The study included 28 patients with mild to moderate acne. They were randomly divided into two equal groups. Group I treated with topical spironolactone 5% gel, and group II treated with topical dapsone 5% gel. In both groups, the gel was applied twice daily for 12 weeks, and patients were evaluated using the acne severity index. Group I included 14 patients [11 (78.6%) females and 3 (21.4%) males]. More than one-half of this group (64.3%) had moderate acne severity. Group II included 14 patients [12 (85.7%) females and 2 (14.3%) males]. Half of patients had moderate acne severity. Therapeutic response was poor, moderate, good, and excellent (14.3%), (28.6%), (50%), (7.1%), respectively, in topical spironolactone group versus poor, moderate, and good (50%), (42.9%), (7.1%), respectively, in topical dapsone group. The therapeutic response between the studied groups was statistically significant in favor of the topical spironolactone group. Regarding adverse effects, burning sensation was evident after application of topical spironolactone while itching was significantly common with topical dapsone. The data provided by the current study support the use of topical spironolactone 5% gel in treating acne vulgaris in both male and female patients.

外用螺内酯与外用地塞米松治疗寻常型痤疮的疗效和安全性对比。
寻常痤疮是一种常见的皮肤病,严重影响患者的生活质量。目前有多种治疗痤疮的方法,但成功率不一。我们的目的是比较 5%螺内酯外用凝胶和 5%地塞松外用凝胶作为寻常痤疮治疗方法的安全性和有效性。这项研究包括 28 名轻度至中度痤疮患者。他们被随机分为两组。第一组外用5%螺内酯凝胶,第二组外用5%地松凝胶。两组患者每天涂抹两次凝胶,持续 12 周,并使用痤疮严重程度指数对患者进行评估。第一组包括 14 名患者[11 名(78.6%)女性,3 名(21.4%)男性]。这组患者中有一半以上(64.3%)的痤疮属于中度严重。第二组包括 14 名患者[12 名(85.7%)女性和 2 名(14.3%)男性]。半数患者的痤疮程度为中度。外用螺内酯组的治疗反应分别为差、中、好、优(14.3%)、(28.6%)、(50%)、(7.1%),而外用达泊松组的治疗反应分别为差、中、好、优(50%)、(42.9%)、(7.1%)。研究组之间的治疗反应在统计学上有显著差异,外用螺内酯组更优。在不良反应方面,局部使用螺内酯后有明显的灼烧感,而局部使用地塞米松则有明显的瘙痒感。本研究提供的数据支持使用 5%螺内酯外用凝胶治疗男女寻常型痤疮。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.10
自引率
3.30%
发文量
30
审稿时长
4-8 weeks
期刊介绍: Archives of Dermatological Research is a highly rated international journal that publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunology of the skin. The journal is among the few not related to dermatological associations or belonging to respective societies which guarantees complete independence. This English-language journal also offers a platform for review articles in areas of interest for dermatologists and for publication of innovative clinical trials.
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