Stem cell–homing biomimetic hydrogel promotes the repair of osteoporotic bone defects through osteogenic and angiogenic coupling

IF 11.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2024-11-01 DOI:10.1126/sciadv.adq6700

Fei-Long Wei, Yuan Zhai, Tian-Fu Wang, Jing-Wei Zhao, Chao-Li Wang, Zhen Tang, Kuo Shen, Hao Wu, Rui Zheng, Ming-Rui Du, Wei Heng, Xiao-Xiang Li, Xiao-Dong Yan, Quan-You Gao, Zheng Guo, Ji-Xian Qian, Cheng-Pei Zhou

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引用次数: 0

Abstract

Osteoporotic bone defects refer to the disruption of bone structural integrity in patients with osteoporosis and pose a substantial challenge to orthopedic surgeons. In this study, we developed a biomimetic hydrogel to improve the osteogenic microenvironment and promote stem cell homing. This hydrogel served as a container for S-nitrosoglutathione and Ca²⁺, promoting the release of bioactive nitric oxide (NO) from bone marrow mesenchymal stem cells (BMSCs) and human vascular endothelial cells and activating the NO/cyclic guanosine monophosphate signaling pathway. These changes promote osteogenic and angiogenic couplings. The hydrogel simultaneously recruited BMSCs by conjugating the stem cell homing peptide SKPPGTSS. Using a rat distal femoral defect model, it was demonstrated that this hydrogel can effectively increase the formation of bone tissue and new blood vessels and has immune-regulating functions. We envision that this hydrogel may be a minimally invasive yet highly effective strategy for expediting the healing of osteoporotic bone defects.

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干细胞归巢生物仿生水凝胶通过成骨和血管生成耦合促进骨质疏松性骨缺损的修复

骨质疏松症骨缺损是指骨质疏松症患者的骨结构完整性遭到破坏，给骨科医生带来了巨大挑战。在这项研究中，我们开发了一种仿生水凝胶，以改善成骨微环境并促进干细胞归巢。这种水凝胶可作为 S-亚硝基谷胱甘肽和 Ca 2+ 的容器，促进骨髓间充质干细胞（BMSCs）和人类血管内皮细胞释放生物活性一氧化氮（NO），并激活 NO/ 环鸟苷一磷酸信号通路。这些变化促进了成骨和血管生成的耦合。该水凝胶同时通过连接干细胞归巢肽 SKPPGTSS 来招募 BMSCs。利用大鼠股骨远端缺损模型证明，这种水凝胶能有效增加骨组织和新生血管的形成，并具有免疫调节功能。我们设想，这种水凝胶可能是一种微创但高效的策略，可加快骨质疏松性骨缺损的愈合。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.