Tissue-resident memory cells in antitumoral immunity and cancer immunotherapy

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2024-10-31 DOI:10.1016/j.coi.2024.102499

Daniel Min , Jacob Fiedler , Niroshana Anandasabapathy

引用次数: 0

Abstract

As cancer immunotherapy evolves, tissue-resident memory (T_RM) cells remain key contributors to the antitumoral immune response due to their ability to mediate local tumor control, high expression of immune checkpoints, potential to respond to immunotherapy, and location across tissue sites where distal tumor metastases occur. This review synthesizes recent findings on the biology of T_RM cells, their role in cancer, and their interactions with the tumor microenvironment. We also identify several critical research gaps, such as how mechanistic interrogation of T_RM cell function is required for integration into therapeutics, proposing a focused research agenda to better exploit their potential.

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抗肿瘤免疫和癌症免疫疗法中的组织驻留记忆细胞

随着癌症免疫疗法的发展，组织驻留记忆（TRM）细胞仍然是抗肿瘤免疫反应的关键因素，因为它们能够介导局部肿瘤控制、高表达免疫检查点、具有对免疫疗法产生反应的潜能以及位于发生远端肿瘤转移的组织部位。本综述综述了有关 TRM 细胞生物学、其在癌症中的作用及其与肿瘤微环境相互作用的最新研究成果。我们还指出了几个关键的研究空白点，例如如何从机理上分析 TRM 细胞的功能才能将其整合到疗法中，并提出了一个重点研究议程，以更好地开发它们的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.