Recent advances in green chemistry approaches for pharmaceutical synthesis

Sageer Ahmad , Rahul Jaiswal , Reetu Yadav , Sarita Verma
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Abstract

Green chemistry has revolutionized pharmaceutical synthesis by promoting sustainability and reducing environmental impact. This review aims to present the recent advancements in the green chemistry approaches that include the principles, novel methods and the application of the methodologies in brief. Beginning with the discussion of the general research background and significance, the review addresses principles of green chemistry such as atom economy, the reduction of waste generation, and the applications of sustainable feedstocks. Closeness to environment solvents choice and catalytic processes are highlighted as well as the priority of uses of bio-catalysis and chemo-enzymatic strategies to reactions improvement and sustainability. Case studies including in this review demonstrate the practical application of green chemistry principles in real-world pharmaceutical manufacturing, showcasing successful implementation and the environmental benefits achieved. It also discusses present day methods like microwave and ultrasound assisted synthesis, flow chemistry, and eco-friendly extraction techniques, making reaction better and using less energy. Examples of good practice for industrial application are described and the possible drawbacks, such as economical, technical, and legal problems, are also discussed. Other aspects of green chemistry, including the scalability of the concepts along with focuses of catalysis, solvents, and reuses of wastes are described herein. Therefore, this review discussed the positive changes brought by green chemistry to the pharmaceutical industry and also pointed out new directions and potential difficulties on this road.
用于药物合成的绿色化学方法的最新进展
绿色化学通过促进可持续发展和减少对环境的影响,彻底改变了药物合成。本综述旨在简要介绍绿色化学方法的最新进展,包括原理、新方法和方法的应用。综述从讨论一般研究背景和意义开始,论述了绿色化学的原则,如原子经济、减少废物产生和可持续原料的应用。重点介绍了溶剂选择和催化过程与环境的密切关系,以及生物催化和化学酶策略在改善反应和可持续性方面的优先应用。本综述中的案例研究展示了绿色化学原理在现实世界制药生产中的实际应用,展示了成功的实施和取得的环境效益。本综述还讨论了微波和超声波辅助合成、流动化学和生态友好型萃取技术等现代方法,使反应更好,能耗更低。书中介绍了工业应用的良好实践范例,还讨论了可能存在的弊端,如经济、技术和法律问题。此外,还介绍了绿色化学的其他方面,包括概念的可扩展性以及催化、溶剂和废物再利用的重点。因此,本综述讨论了绿色化学给制药业带来的积极变化,同时也指出了这条道路上的新方向和潜在困难。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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