Is lateralization concordance between preoperative video-EEG, ictal SPECT, and MRI to be associated with positive psychiatric outcomes after cortico-amygdalohippocampectomy in patients with pharmacoresistant temporal lobe epilepsy associated to mesial temporal sclerosis? A retrospective cohort study

Abstract

Objective

The occurrence of comorbid psychiatric disorders (PD) in patients with pharmacoresistant temporal lobe epilepsy (TLE) associated to mesial temporal sclerosis (MTS) can be considered as a result of the complex interaction between biological and psychosocial factors, as well as the effects of antiseizure medications (ASM). Regarding biological aspects, despite the growing amount of knowledge, there is still a scarcity of data in literature clarifying whether a more precise definition of the seizure onset zone (SOZ) could be associated with a more favorable post-surgical psychiatric outcome. In the present study, the clinical and sociodemographic pre-surgical variables, including the results of neurophysiological and neuroimaging exams, were evaluated in patients with pharmacoresistant TLE-MTS aiming to investigate possible risk factors for the presence of PD after cortico-amygdalohippocampectomy (CAH).

Methods

A retrospective cohort analysis of medical records from initially 106 pre-surgical patients with pharmacoresistant TLE-MTS with PD (n = 51; 48.1 %) and without PD (n = 55; 51.9 %) proceeded. Pre-surgical clinical and sociodemographic data were compared between both groups and the predictors for the presence of post-surgical PD were characterized up to one and two years after CAH.

Results

Seventeen patients (16 %) had lost their follow-up in the first year after surgery, and 89 (84 %) had completed the study. No clinical and sociodemographic differences were observed between both groups of patients (p > 0.05), except for a history of previous psychiatric treatment (p = 0.001). Eighteen patients (35.29 %) with pre-surgical history of PD had remission of PD after CAH, while eight (14.5 %) developed de novo PD. The previous history of PD was directly associated with the development of post-surgical PD one year after CAH (p < 0.0001). Previous psychiatric treatment (p < 0.01), previous history of mood (p = 0.002) and anxiety (p = 0.03) disorder, as well as discordance in lateralization between MRI, SPECT, and EEG (p = 0.02), were predictors for the development of PD two years after CAH. Post-surgical psychiatric outcomes were associated to seizure outcome based on the Engel classification (p < 0,0001).

Conclusion

The present data observed an association between lateralization concordance of results of pre-surgical investigative exams and positive postoperative psychiatric outcomes in patients with pharmacoresistant TLE-MTS. These results could suggest that a more precise definition of the SOZ could be associated with a more favorable post-surgical psychiatric outcome after CAH.