Molecular role of miR-152-3p, miR-296-5p and miR-185-5p in urinary bladder cancer etiology

Abstract

Bladder cancer is the tenth most common type of cancer worldwide. The lack of better diagnostic methods and effective treatments make it highly lethal. However, miRNAs are emerging as critical elements in diagnosing various diseases, especially cancers. Therefore, in the pursuit of improved diagnostic tools, this review aims to assess miRNAs interacting with their target genes in bladder cancer and evaluate the most significant miRNAs based on their molecular roles. After analyzing the literature and using several in-silico tools (e.g., miRWalk, miRDB, miRTarBase, TargetScan), we found that three miRNAs (miR-152-3p, miR-296-5p, miR-185-5p) out of a total of 1468 miRNAs were highly associated with bladder cancer, targeting three important genes: FGFR3, PTEN and PMF1. These three miRNAs may potentially serve as a panel for the diagnosis of bladder cancer after validation through extensive in-vitro and in-vivo studies. Moreover, these miRNAs could also be considered for therapeutic intervention against bladder cancer, following proper validation through in vivo studies.