Flll32, a curcumin analog, improves adipose tissue thermogenesis

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical and biophysical research communications Pub Date : 2024-10-28 DOI:10.1016/j.bbrc.2024.150919

Zeyu Guo , Enhui Chen , Xianghong Xie , Yanfang Guo , Minglong Zhang , Yinghan Zhu , Yiting Wang , Fude Fang , Li Yan , Xiaojun Liu

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引用次数: 0

Abstract

Adipose tissue is a key regulator of systemic energy homeostasis and improving adipose tissue function provides a brand-new theoretical reference for the prevention and treatment of obesity. FLLL32, a curcumin analog, can hinder various carcinogenic processes, however, its role in adipose tissue has not been fully elucidated. In this study, we observed that FLLL32 treatment significantly improved cold intolerance and reduced white adipose tissue (WAT) adipocyte size in mice, but had no effect on body weight and adipose tissues weight. Furthermore, FLLL32 treatment upregulated the expression level of uncoupling protein 1 and downregulated the expression level of peroxisome proliferator-activated receptor gamma in adipose tissue. Additionally, FLLL32 promoted the mRNA level of transferrin receptor protein 1, a key iron transporter on the cell membrane, and the lipid peroxidation in inguinal WAT. Finally, FLLL32 significantly inhibited the differentiation and maturation of preadipocytes. In summary, our results demonstrated that FLLL32 plays a crucial role in regulating adipose tissue function.

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姜黄素类似物 Flll32 可改善脂肪组织的生热功能

脂肪组织是全身能量平衡的关键调节器，改善脂肪组织的功能为预防和治疗肥胖症提供了全新的理论参考。姜黄素类似物 FLLL32 可以抑制多种致癌过程，但其在脂肪组织中的作用尚未完全阐明。在这项研究中，我们观察到，FLLL32能明显改善小鼠的耐寒能力，减少白色脂肪组织（WAT）脂肪细胞的体积，但对体重和脂肪组织重量没有影响。此外，FLL32 还能上调脂肪组织中解偶联蛋白 1 的表达水平，下调过氧化物酶体增殖激活受体 gamma 的表达水平。此外，FLL32 还能促进腹股沟脂肪组织中转铁蛋白受体蛋白 1（一种细胞膜上的关键铁转运体）的 mRNA 水平和脂质过氧化反应。最后，FLL32 能明显抑制前脂肪细胞的分化和成熟。总之，我们的研究结果表明，FLL32 在调节脂肪组织功能方面起着至关重要的作用。

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来源期刊

Biochemical and biophysical research communications 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

1400

审稿时长

14 days

期刊介绍： Biochemical and Biophysical Research Communications is the premier international journal devoted to the very rapid dissemination of timely and significant experimental results in diverse fields of biological research. The development of the "Breakthroughs and Views" section brings the minireview format to the journal, and issues often contain collections of special interest manuscripts. BBRC is published weekly (52 issues/year).Research Areas now include: Biochemistry; biophysics; cell biology; developmental biology; immunology ; molecular biology; neurobiology; plant biology and proteomics