Polymer microsphere inks for semi-solid extrusion 3D printing at ambient conditions

IF 3.3 2区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-10-16 DOI:10.1016/j.jmbbm.2024.106783

Juuso Pohjola , Mika Jokinen , Tero Soukka , Mikael Stolt

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Abstract

Extrusion-based 3D printing methods have great potential for manufacturing of personalized polymer-based drug-releasing systems. However, traditional melt-based extrusion techniques are often unsuitable for processing thermally labile molecules. Consequently, methods that utilize the extrusion of semi-solid inks under mild conditions are frequently employed. The rheological properties of the semi-solid inks have a substantial impact on the 3D printability, making it necessary to evaluate and tailor these properties. Here, we report a novel semi-solid extrusion 3D printing method based on utilization of a Carbopol gel matrix containing various concentrations of polymeric microspheres. We also demonstrate the use of a solvent vapor-based post-processing method for enhancing the mechanical strength of the printed objects. As our approach enables room-temperature processing of polymers typically used in the pharmaceutical industry, it may also facilitate the broader application of 3D printing and microsphere technologies in preparation of personalized medicine.

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用于环境条件下半固态挤压 3D 打印的聚合物微球油墨

基于挤压的三维打印方法在制造个性化聚合物药物释放系统方面具有巨大潜力。然而，传统的熔融挤压技术往往不适合处理热敏性分子。因此，人们经常采用在温和条件下挤压半固态油墨的方法。半固态油墨的流变特性对三维打印性能有很大影响，因此有必要对这些特性进行评估和定制。在此，我们报告了一种新型半固态挤压三维打印方法，该方法基于含有不同浓度聚合物微球的 Carbopol 凝胶基质。我们还展示了如何使用基于溶剂蒸汽的后处理方法来增强打印物体的机械强度。由于我们的方法能够在室温下加工制药业通常使用的聚合物，因此还能促进三维打印和微球技术在制备个性化药物方面的更广泛应用。

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来源期刊

Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学：生物材料

CiteScore

7.20

自引率

7.70%

发文量

505

审稿时长

46 days

期刊介绍： The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.