Tumor treating induced fields: a new treatment option for patients with glioblastoma.

IF 2.7 3区医学 Q2 CLINICAL NEUROLOGY

Frontiers in Neurology Pub Date : 2024-10-17 eCollection Date: 2024-01-01 DOI:10.3389/fneur.2024.1413236

Zehao Cai, Zukai Yang, Ying Wang, Ye Li, Hong Zhao, Hanwen Zhao, Xue Yang, Can Wang, Tengteng Meng, Xiao Tong, Hao Zheng, Zhaoyong He, Chunli Niu, Junzhi Yang, Feng Chen, Zhi Yang, Zhige Zou, Wenbin Li

{"title":"Tumor treating induced fields: a new treatment option for patients with glioblastoma.","authors":"Zehao Cai, Zukai Yang, Ying Wang, Ye Li, Hong Zhao, Hanwen Zhao, Xue Yang, Can Wang, Tengteng Meng, Xiao Tong, Hao Zheng, Zhaoyong He, Chunli Niu, Junzhi Yang, Feng Chen, Zhi Yang, Zhige Zou, Wenbin Li","doi":"10.3389/fneur.2024.1413236","DOIUrl":null,"url":null,"abstract":"Purpose: Currently, a range of electromagnetic therapies, including magnetic field therapy, micro-currents therapy, and tumor treating fields, are under investigation for their potential in central nervous system tumor research. Each of these electromagnetic therapies possesses distinct effects and limitations. Our focus is on overcoming these limitations by developing a novel electric field generator. This generator operates by producing alternating induced currents within the tumor area through electromagnetic induction.Methods: Finite element analysis was employed to calculate the distribution of electric fields. Cell viability was assessed using the CCK-8 assay. Tumor volumes and weights served as indicators to evaluate the effectiveness of TTIF. The in-vivo imaging system was utilized to confirm tumor growth in the brains of mice.Results: TTIF significantly inhibited the proliferation of U87 cells both in vitro and in vivo.Conclusion: TTIF significantly inhibited the proliferation of U87 cells both in vitro and in vivo. Consequently, TTIF emerges as a potential treatment option for patients with progressive or metastatic GBM.","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"15 ","pages":"1413236"},"PeriodicalIF":2.7000,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524832/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fneur.2024.1413236","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Currently, a range of electromagnetic therapies, including magnetic field therapy, micro-currents therapy, and tumor treating fields, are under investigation for their potential in central nervous system tumor research. Each of these electromagnetic therapies possesses distinct effects and limitations. Our focus is on overcoming these limitations by developing a novel electric field generator. This generator operates by producing alternating induced currents within the tumor area through electromagnetic induction.

Methods: Finite element analysis was employed to calculate the distribution of electric fields. Cell viability was assessed using the CCK-8 assay. Tumor volumes and weights served as indicators to evaluate the effectiveness of TTIF. The in-vivo imaging system was utilized to confirm tumor growth in the brains of mice.

Results: TTIF significantly inhibited the proliferation of U87 cells both in vitro and in vivo.

Conclusion: TTIF significantly inhibited the proliferation of U87 cells both in vitro and in vivo. Consequently, TTIF emerges as a potential treatment option for patients with progressive or metastatic GBM.

查看原文本刊更多论文

肿瘤治疗诱导场：胶质母细胞瘤患者的新治疗方案。

目的：目前，一系列电磁疗法，包括磁场疗法、微电流疗法和肿瘤治疗场，都在研究其在中枢神经系统肿瘤研究中的潜力。这些电磁疗法各有不同的效果和局限性。我们的重点是通过开发一种新型电场发生器来克服这些局限性。这种发生器的工作原理是通过电磁感应在肿瘤区域内产生交变感应电流：方法：采用有限元分析计算电场分布。使用 CCK-8 检测法评估细胞活力。肿瘤体积和重量是评估 TTIF 效果的指标。利用体内成像系统确认小鼠大脑中的肿瘤生长情况：结果：TTIF在体外和体内都能明显抑制U87细胞的增殖：结论：TTIF 在体外和体内都能明显抑制 U87 细胞的增殖。因此，TTIF 成为进展性或转移性 GBM 患者的一种潜在治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Neurology CLINICAL NEUROLOGYNEUROSCIENCES -NEUROSCIENCES

CiteScore

4.90

自引率

8.80%

发文量

2792

审稿时长

14 weeks

期刊介绍： The section Stroke aims to quickly and accurately publish important experimental, translational and clinical studies, and reviews that contribute to the knowledge of stroke, its causes, manifestations, diagnosis, and management.