Association of chronic arsenic exposure with cellular immune profile in MINIMat adolescents: A birth cohort in Bangladesh

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-10-30 DOI:10.1016/j.etap.2024.104583

Farjana Haque , Evana Akhtar , Bikash Chandra Chanda , Anjuman Ara , Md.Ahsanul Haq , Protim Sarker , Maria Kippler , Yukiko Wagatsuma , Ondine S. von Ehrenstein , Rubhana Raqib

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Abstract

Chronic arsenic exposure is known to affect the immune system. We aimed to evaluate the association between arsenic exposure and immune cell profile in 15 years old adolescents (n=389) in rural Bangladesh, with chronic exposure to groundwater arsenic. Single blood and urine were collected. Urinary arsenic (U-As) concentration was measured using atomic absorption spectrometry. Peripheral blood mononuclear cells (PBMC) were analyzed by flow cytometry. Non-linear association was found between U-As (median, 24.9 µg/L) and immune cells with a cut-off at U-As 20 µg/L. U-As (<20 µg/L) were significantly associated with increases in CD8⁺T (21 %), na^ïve CD8⁺T (42 %) and early B cells (40 %), and classical monocytes (55 %), but reduction in CD3⁺T cells (37^%) and intermediate-monocytes (56 %). U-As (>20 µg/L) were associated with a 3 % reduction in memory B cells. Arsenic exposure was associated with altered immune cell profile in adolescents likely rendering them vulnerable to adverse health effects in later life.

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慢性砷暴露与 MINIMat 青少年细胞免疫特征的关系：孟加拉国出生队列

众所周知，长期接触砷会影响免疫系统。我们的目的是评估长期暴露于地下水砷的孟加拉国农村地区 15 岁青少年（人数=389）的砷暴露与免疫细胞特征之间的关系。我们采集了单次血液和尿液。使用原子吸收光谱法测量尿砷（U-As）浓度。外周血单核细胞（PBMC）采用流式细胞术进行分析。结果发现，U-As（中位数，24.9 微克/升）与免疫细胞之间存在非线性关联，U-As 20 微克/升为分界线。U-As（+T细胞（21%）、幼稚CD8+T细胞（42%）、早期B细胞（40%）和典型单核细胞（55%），但CD3+T细胞（37%）和中间单核细胞（56%）减少。U-砷（>20 微克/升）与记忆 B 细胞减少 3% 有关。砷暴露与青少年免疫细胞谱的改变有关，可能使他们在以后的生活中容易受到不良健康影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.