Influence of genetic polymorphism on sports talent performance versus non-athletes: a systematic review and meta-analysis.

IF 2.1 3区医学 Q1 REHABILITATION

BMC Sports Science Medicine and Rehabilitation Pub Date : 2024-10-31 DOI:10.1186/s13102-024-01001-5

Cirley Pinheiro Ferreira, Valmir Oliveira Silvino, Rebeca Gonçalves Trevisano, Rayane Carvalho de Moura, Sandro Soares Almeida, Marcos Antonio Pereira Dos Santos

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引用次数: 0

Abstract

Background: Talented athletes exhibit remarkable skills and performance in their respective sports, setting them apart from their peers. It has been observed that genetic polymorphisms can influence variations in sports performance, leading to numerous studies aimed at validating genetic markers for identifying sports talents. This study aims to evaluate the potential contribution of genetic factors associated with athletic performance predisposition in identifying sports talents.

Methods: A systematic review was conducted following the PRISMA framework, utilizing the PICO methodology to develop the research question. The search was limited to case-control studies published between 2003 and June 2024, and databases such as Medline, LILACS, WPRIM, IBECS, CUMED, VETINDEX, Web of Science, Science Direct, Scopus and Scielo were utilized. The STREGA tool was employed to assess the quality of the selected studies.

Results: A total of 1,132 articles were initially identified, of which 119 studies were included in the review. Within these studies, 50 genes and 94 polymorphisms were identified, showing associations with sports talent characteristics such as endurance, strength, power, and speed. The most frequently mentioned genes were ACTN3 (27.0%) and ACE (11.3%).

Conclusion: The ACE I/D and ACTN3 R577X polymorphisms are frequently discussed in the literature. Although athletic performance may be influenced by different genetic polymorphisms, limitations exist in associating them with athletic performance across certain genotypes and phenotypes. Future research is suggested to investigate the influence of polymorphisms in elite athletes from diverse backgrounds and sports disciplines.

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基因多态性对体育人才与非运动员成绩的影响：系统回顾与荟萃分析。

背景：天才运动员在各自的运动项目中表现出非凡的技能和成绩，使他们在同龄人中脱颖而出。据观察，基因多态性可影响运动成绩的变化，因此有许多研究旨在验证用于识别体育人才的遗传标记。本研究旨在评估与运动表现倾向相关的遗传因素在识别体育人才方面的潜在贡献：方法：按照 PRISMA 框架，利用 PICO 方法对研究问题进行了系统综述。检索仅限于 2003 年至 2024 年 6 月间发表的病例对照研究，使用的数据库包括 Medline、LILACS、WPRIM、IBECS、CUMED、VETINDEX、Web of Science、Science Direct、Scopus 和 Scielo。采用 STREGA 工具评估所选研究的质量：结果：共初步确定了 1,132 篇文章，其中 119 项研究被纳入综述。在这些研究中，发现了 50 个基因和 94 个多态性，它们与运动天赋特征（如耐力、力量、力量和速度）有关。最常被提及的基因是 ACTN3（27.0%）和 ACE（11.3%）：结论：文献中经常讨论 ACE I/D 和 ACTN3 R577X 多态性。虽然运动成绩可能会受到不同基因多态性的影响，但将它们与某些基因型和表型的运动成绩联系起来还存在局限性。建议今后开展研究，调查多态性对来自不同背景和运动学科的精英运动员的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Sports Science Medicine and Rehabilitation Medicine-Orthopedics and Sports Medicine

CiteScore

3.00

自引率

5.30%

发文量

196

审稿时长

26 weeks

期刊介绍： BMC Sports Science, Medicine and Rehabilitation is an open access, peer reviewed journal that considers articles on all aspects of sports medicine and the exercise sciences, including rehabilitation, traumatology, cardiology, physiology, and nutrition.