Non-alcoholic Wernicke Encephalopathy in a Young Patient with Adenocarcinoma of the Colon: A Case Report and Review of the Literature.

IF 1.4 Q4 PHARMACOLOGY & PHARMACY
Afroditi Ziogou, Andreas Lymperis, Nikolaos Skouteris, Georgios Papageorgiou, Nikolaos Charalampakis
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引用次数: 0

Abstract

Introduction: Wernicke Encephalopathy (W.E.) is an acute neurological disorder induced by thiamine deficiency. Alcohol abuse is considered to be the leading cause of the disease; however, numerous other conditions, such as malnutrition or cancer, have been identified as potential risk factors.

Case presentation: Clinical manifestations include a typical triad of mental status alteration, nystagmus, and ataxia and are attributed to damage in brain regions of high thiamine demand. The diagnosis is mainly clinical and further supported by the immediate response of neurological signs to parenteral thiamine administration. Among paraclinical examinations, brain MRI is considered substantial for diagnosis and is supported by the determination of thiamine blood levels.

Conclusion: Non-alcoholic W.E. is trickier to diagnose due to its atypical clinical course and risk factors. We herein describe a case of non-alcoholic W.E. in a woman with colon cancer who gradually developed the classic symptoms of thiamine deficiency.

结肠腺癌年轻患者的非酒精性韦尼克脑病:病例报告和文献综述。
导言韦尼克脑病(Wernicke Encephalopathy,W.E.)是一种由硫胺素缺乏引起的急性神经系统疾病。酗酒被认为是导致该病的主要原因,然而,营养不良或癌症等许多其他疾病也被认为是潜在的危险因素:临床表现包括典型的精神状态改变、眼球震颤和共济失调三联征,归因于对硫胺素需求较高的脑区受损。诊断主要依靠临床表现,而神经系统体征对肠道外注射硫胺素的即时反应则进一步证实了这一点。在辅助临床检查中,脑核磁共振成像被认为是诊断的重要依据,并通过测定血液中的硫胺素水平来支持诊断:结论:非酒精性 W.E. 由于其不典型的临床过程和风险因素,诊断起来较为棘手。我们在此描述了一例患有结肠癌的女性非酒精性 W.E.患者,她逐渐出现了典型的硫胺素缺乏症状。
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来源期刊
Reviews on recent clinical trials
Reviews on recent clinical trials PHARMACOLOGY & PHARMACY-
CiteScore
3.10
自引率
5.30%
发文量
44
期刊介绍: Reviews on Recent Clinical Trials publishes frontier reviews on recent clinical trials of major importance. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: important Phase I – IV clinical trial studies, clinical investigations at all stages of development and therapeutics. The journal is essential reading for all researchers and clinicians involved in drug therapy and clinical trials.
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