Wound healing after surgical therapy for multiple myeloma: a case-control study.

IF 1.5 4区 医学 Q3 DERMATOLOGY
Xiangjun Shi, Yanyou Zhou, Boran Du, Xingchen Yao, Xinru Du
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Abstract

Objective: The aim of this study was to observe the surgical wound healing process in patients with multiple myeloma who had undergone surgery.

Method: We collected clinical data on patients with multiple myeloma and observed wound healing following surgical therapy. Additionally, we compared the expression of angiogenesis markers in patients with and without multiple myeloma (undergoing surgical excision of other tumour tissues). In patients who had multiple myeloma bone disease, we examined several clinical features: haemoglobin levels; albumin levels; blood glucose levels; and surgery programme. We then compared expression levels of the angiogenesis markers CD31, CD34 and vascular endothelial growth factor (VEGF) in samples scraped from the skin margin of the surgical incision in 12 patients without multiple myeloma (control) and nine patients with multiple myeloma.

Results: All 61 patients with multiple myeloma observed showed no disunion, no delayed union and no infection in their wound healing. CD31 and VEGF expression was higher in the nine patients with multiple myeloma compared with the 12 control patients without. We observed no difference in CD34 expression between control and experimental groups.

Conclusion: The results of this study suggest that patients with multiple myeloma who have undergone surgery recover well and produce higher quantities of new vessels compared with patients without multiple myeloma. This occurs through increased expression of CD31 and VEGF, angiogenic factors which promote wound healing. We did not observe higher expression of these factors contributing to increased incisional implantation metastasis.

多发性骨髓瘤手术治疗后的伤口愈合:一项病例对照研究。
研究目的本研究旨在观察接受手术治疗的多发性骨髓瘤患者的伤口愈合过程:我们收集了多发性骨髓瘤患者的临床数据,并观察了手术治疗后的伤口愈合情况。此外,我们还比较了多发性骨髓瘤患者和非多发性骨髓瘤患者(接受手术切除其他肿瘤组织)血管生成标志物的表达情况。在患有多发性骨髓瘤骨病的患者中,我们检查了一些临床特征:血红蛋白水平、白蛋白水平、血糖水平和手术方案。然后,我们比较了 12 名非多发性骨髓瘤患者(对照组)和 9 名多发性骨髓瘤患者手术切口皮肤边缘刮取样本中血管生成标志物 CD31、CD34 和血管内皮生长因子(VEGF)的表达水平:结果:所观察的61例多发性骨髓瘤患者在伤口愈合过程中均未出现脱落、延迟愈合和感染。与 12 名对照组非多发性骨髓瘤患者相比,9 名多发性骨髓瘤患者的 CD31 和 VEGF 表达较高。我们观察到,对照组和实验组的 CD34 表达没有差异:本研究结果表明,与未患多发性骨髓瘤的患者相比,接受手术治疗的多发性骨髓瘤患者恢复良好,并产生更多的新生血管。这是由于促进伤口愈合的血管生成因子 CD31 和血管内皮生长因子的表达增加所致。我们没有观察到这些因子的高表达会导致切口种植转移的增加。
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来源期刊
Journal of wound care
Journal of wound care DERMATOLOGY-
CiteScore
2.90
自引率
10.50%
发文量
215
期刊介绍: Journal of Wound Care (JWC) is the definitive wound-care journal and the leading source of up-to-date research and clinical information on everything related to tissue viability. The journal was first launched in 1992 and aimed at catering to the needs of the multidisciplinary team. Published monthly, the journal’s international audience includes nurses, doctors and researchers specialising in wound management and tissue viability, as well as generalists wishing to enhance their practice. In addition to cutting edge and state-of-the-art research and practice articles, JWC also covers topics related to wound-care management, education and novel therapies, as well as JWC cases supplements, a supplement dedicated solely to case reports and case series in wound care. All articles are rigorously peer-reviewed by a panel of international experts, comprised of clinicians, nurses and researchers. Specifically, JWC publishes: High quality evidence on all aspects of wound care, including leg ulcers, pressure ulcers, the diabetic foot, burns, surgical wounds, wound infection and more The latest developments and innovations in wound care through both preclinical and preliminary clinical trials of potential new treatments worldwide In-depth prospective studies of new treatment applications, as well as high-level research evidence on existing treatments Clinical case studies providing information on how to deal with complex wounds Comprehensive literature reviews on current concepts and practice, including cost-effectiveness Updates on the activities of wound care societies around the world.
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