Evaluation of serum BDNF, IL-1β, and IL-6 levels alongside assessing mental health and life satisfaction in sulfur mustard-chemical veterans.

IF 4.8 2区 医学 Q2 IMMUNOLOGY
International immunopharmacology Pub Date : 2024-12-25 Epub Date: 2024-10-30 DOI:10.1016/j.intimp.2024.113479
Gholam-Hossein Ghaedi, Leila Nasiri, Hossein Hassanpour, Mohammad Mehdi Naghizadeh, Ahmad Abdollahzadeh, Tooba Ghazanfari
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引用次数: 0

Abstract

Sulfur mustard (SM), a chemical warfare weapon has been used in conflicts. The delayed impact of sulfur mustard on mental and physical health of veterans remains a topic of significant concern. This cross-sectional study investigated the serum levels of brain-derived neurotrophic factor (BDNF), interleukin (IL)-1β, and IL-6 in 227 SM-chemical veterans receiving long-term financial support and 77 healthy individuals. Their mental health status and life satisfaction were assessed through three self-report questionnaires (General Health Questionnaire - 28, GHQ-28; Depression, Anxiety & Stress Scale, DASS-21; 36-Item Short Form Survey, SF-36). Our findings revealed higher levels of anxiety/insomnia, and psychiatric symptoms in the veterans compared to the control group (P < 0.05), accompanied by depression, stress, and anxiety as measured by the GHQ-28 and DASS-21 assessments. Severe depression and social dysfunction were not prevalent in the veterans compared to the control group (P > 0.05) according to the GHQ-28 findings. The SF-36 assessment indicated overall better health conditions for SM participants, with higher scores across various domains (general health, social function, and mental health) and two mental and physical dimensions in the veterans compared to the control group (P < 0.05). IL-1β and IL-6 levels were lower in the SM-exposed group than in the control group, while the BDNF level was higher in the SM-exposed group (P < 0.05). Alterations in BDNF, IL-1β, and IL-6 levels along with results of the mentioned questionnaires may be evidence of partial improvement in the mental and physical health of the SM-exposed individuals receiving the financial support.

评估血清 BDNF、IL-1β 和 IL-6 水平,同时评估硫芥子气化学退伍军人的心理健康和生活满意度。
硫芥子气(SM)是一种化学战武器,曾在冲突中使用过。硫芥子气对退伍军人身心健康的延迟影响仍然是一个备受关注的话题。这项横断面研究调查了 227 名接受长期资助的硫芥子气化学退伍军人和 77 名健康人血清中脑源性神经营养因子 (BDNF)、白细胞介素 (IL)-1β 和 IL-6 的水平。他们的心理健康状况和生活满意度通过三份自我报告问卷(一般健康问卷-28,GHQ-28;抑郁、焦虑和压力量表,DASS-21;36项简表调查,SF-36)进行评估。根据 GHQ-28 的结果,我们发现退伍军人的焦虑/失眠和精神症状水平高于对照组(P 0.05)。SF-36 评估表明,退伍军人的总体健康状况较好,与对照组相比,退伍军人在各个领域(一般健康、社会功能和心理健康)以及心理和生理两个维度上的得分更高(P.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.40
自引率
3.60%
发文量
935
审稿时长
53 days
期刊介绍: International Immunopharmacology is the primary vehicle for the publication of original research papers pertinent to the overlapping areas of immunology, pharmacology, cytokine biology, immunotherapy, immunopathology and immunotoxicology. Review articles that encompass these subjects are also welcome. The subject material appropriate for submission includes: • Clinical studies employing immunotherapy of any type including the use of: bacterial and chemical agents; thymic hormones, interferon, lymphokines, etc., in transplantation and diseases such as cancer, immunodeficiency, chronic infection and allergic, inflammatory or autoimmune disorders. • Studies on the mechanisms of action of these agents for specific parameters of immune competence as well as the overall clinical state. • Pre-clinical animal studies and in vitro studies on mechanisms of action with immunopotentiators, immunomodulators, immunoadjuvants and other pharmacological agents active on cells participating in immune or allergic responses. • Pharmacological compounds, microbial products and toxicological agents that affect the lymphoid system, and their mechanisms of action. • Agents that activate genes or modify transcription and translation within the immune response. • Substances activated, generated, or released through immunologic or related pathways that are pharmacologically active. • Production, function and regulation of cytokines and their receptors. • Classical pharmacological studies on the effects of chemokines and bioactive factors released during immunological reactions.
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