An exploratory analysis on the association between suicidal ideation and the microbiome in patients with or without major depressive disorder

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2024-10-29 DOI:10.1016/j.jad.2024.10.120

Vincent Chin-Hung Chen , Shu-I Wu

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引用次数: 0

Abstract

Background

Scarce research has investigated associations between suicidal ideation and the gut microbiota. We aimed to explore variations in the gut microbiome associated with suicidal ideation and major depressive disorder (MDD).

Method

A case-control study compared abundances of fecal microbiota and biomarkers of gut permeability among patients with MDD, with or without suicidal ideation, and healthy volunteers without depression. Information on demographic variables and assessments of suicidal ideation (Beck Suicidal Ideation Scale), depression (Hamilton Depression Scale, Patient Health Questionnaire, Hospital Anxiety and Depression Scale- Depression), as well as anxiety (Hospital Anxiety and Depression Scale- Anxiety), were obtained. Univariate and multivariate regression model was performed to explore the possible predictors of suicidal ideation.

Results

Among the 140 participants, significant differences in Beta diversity were found between MDD patients with (n = 43) or without suicidal ideation (n = 34), and healthy volunteers (n = 42) (all p < 0.001). The strain of g-Phascolarctobacterium was found to have significant positive associations with scores of BSSI and BSSI Part 1 (suicidal ideation), particularly in MDD patients with suicidal ideation, after controlling for demographic and mood covariates. Mediation analyses revealed that g-Phascolarctobacterium may be a partial mediator between depression and suicidal ideation; however, it is also possible that the association between g-Phascolarctobacterium and suicidal ideation was partially mediated by the level of depression.

Conclusion

We found different compositions, diversities, and possible mediating of the gut microbiome associated with suicidal ideations. Potential mechanisms need further investigation to establish whether this reflects a biological process that might be the focus for intervention development.

Synopsis

Our objective was to investigate whether the diversities and abundances of the gut microbiome varied in people with or without suicidal ideation and with or without MDD after considering possible demographic and mood confounders.

查看原文本刊更多论文

对患有或未患有重度抑郁症患者的自杀意念与微生物组之间的关系进行探索性分析。

背景：很少有研究调查自杀意念与肠道微生物群之间的关系。我们旨在探索与自杀意念和重度抑郁障碍（MDD）相关的肠道微生物群变化：一项病例对照研究比较了有或没有自杀意念的重度抑郁症患者和无抑郁症的健康志愿者的粪便微生物群丰度和肠道通透性生物标志物。研究人员收集了人口统计学变量、自杀意念评估（贝克自杀意念量表）、抑郁评估（汉密尔顿抑郁量表、患者健康问卷、医院焦虑和抑郁量表-抑郁）以及焦虑评估（医院焦虑和抑郁量表-焦虑）等信息。通过单变量和多变量回归模型探讨自杀意念的可能预测因素：在 140 名参与者中，有自杀意念的 MDD 患者（43 人）和无自杀意念的 MDD 患者（34 人）与健康志愿者（42 人）在 Beta 多样性方面存在明显差异（均为 p）：我们发现了与自杀意念相关的肠道微生物组的不同组成、多样性和可能的中介作用。潜在的机制需要进一步研究，以确定这是否反映了一种生物过程，而这种生物过程可能是开发干预措施的重点：我们的目的是研究在考虑了可能的人口统计学和情绪混杂因素后，有或没有自杀意念、有或没有MDD的人群中肠道微生物组的多样性和丰度是否存在差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.