Punctate hyperreflective vitreous opacities: a ubiquitous finding in healthy children beyond infancy.

IF 2.8 3区医学 Q1 OPHTHALMOLOGY

Eye Pub Date : 2024-10-31 DOI:10.1038/s41433-024-03434-1

May Cohen, Omer Dor, Daphna Mezad-Koursh, Anat Loewenstein, Dinah Zur

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引用次数: 0

Abstract

Background: The vitreous evolves from birth over lifetime. Little is known about the appearance of the healthy vitreous during childhood. We aimed to characterise posterior vitreous features in healthy children using spectral domain optical coherence tomography (SD-OCT).

Methods: Retrospective cohort study including healthy eyes of 78 children aged 2-12 years and 39 healthy adults. Patients diagnosed with intraocular inflammation or vitreoretinal pathology were excluded.

Main outcome: Proportion of eyes with presence of punctate hyperreflective vitreous opacities (PHVO). Percentage of B-scans demonstrating PHVO within an OCT volume scan, correlation between presence of PHVO and patients' age group, retinal measurements, and presence of premacular bursa were analysed.

Results: 154 paediatric eyes (median age 9.08 (IQR 5.17-9.75) years) and 76 adult eyes (30.75 (IQR 26.42-38.08) years) were included; 12244 OCT images were reviewed. All eyes (100%) in the paediatric group and 73% in the adult group presented PHVO. The median percentage of OCT images showing PHVO was 77.05% (IQR 51.23-88.52) in children and 8.0% (IQR 0-16.03) in adults (p < 0.001). Separate analysis of right and left eyes confirmed the results (p < 0001). Premacular bursa appeared in 20.5% of paediatric and 31.6% of adult eyes (p = 0.103). Mean central subfield thickness was significantly lower in children (257 ± 21 µm vs. 276 ± 18 µm, p < 0.001), while median total macular volume was similar (8.59 (IQR 8.25-8.86) mm³ vs. 8.62 (IQR 8.39-8.96) mm³, p = 0.145).

Conclusions: This study demonstrates that PHVO are ubiquitous physiologic vitreous findings in healthy children beyond infancy. These findings enhance the understanding of the development of the posterior segment of the eye and might improve paediatric OCT interpretation, potentially avoiding misdiagnoses and unnecessary interventions in children.

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点状高反射玻璃体混浊：健康儿童在婴儿期后的普遍发现。

背景：玻璃体从出生到终生都在发生变化。人们对儿童期健康玻璃体的外观知之甚少。我们旨在使用光谱域光学相干断层扫描（SD-OCT）来描述健康儿童玻璃体后部的特征：回顾性队列研究，包括 78 名 2-12 岁儿童和 39 名健康成人的健康眼睛。主要结果：存在点状高反射玻璃体混浊（PHVO）的眼睛比例。主要结果：分析在 OCT 容量扫描中显示 PHVO 的 B 扫描百分比、PHVO 的存在与患者年龄组、视网膜测量值以及是否存在玻璃体前囊之间的相关性：共纳入 154 只儿童眼（中位年龄为 9.08 岁（IQR 5.17-9.75 岁））和 76 只成人眼（中位年龄为 30.75 岁（IQR 26.42-38.08 岁））；共审查了 12244 张 OCT 图像。所有儿童眼（100%）和成人眼（73%）均出现 PHVO。显示 PHVO 的 OCT 图像的中位百分比为：儿童 77.05%（IQR 51.23-88.52），成人 8.0%（IQR 0-16.03）（P 3 vs. 8.62（IQR 8.39-8.96）mm3，P = 0.145）：本研究表明，PHVO 是婴儿期以后健康儿童玻璃体中普遍存在的生理现象。这些发现加深了人们对眼球后段发育的理解，并可能改善儿科 OCT 的解释，从而避免误诊和对儿童进行不必要的干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eye 医学-眼科学

CiteScore

6.40

自引率

5.10%

发文量

481

审稿时长

3-6 weeks

期刊介绍： Eye seeks to provide the international practising ophthalmologist with high quality articles, of academic rigour, on the latest global clinical and laboratory based research. Its core aim is to advance the science and practice of ophthalmology with the latest clinical- and scientific-based research. Whilst principally aimed at the practising clinician, the journal contains material of interest to a wider readership including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science worldwide. Eye is the official journal of The Royal College of Ophthalmologists. Eye encourages the submission of original articles covering all aspects of ophthalmology including: external eye disease; oculo-plastic surgery; orbital and lacrimal disease; ocular surface and corneal disorders; paediatric ophthalmology and strabismus; glaucoma; medical and surgical retina; neuro-ophthalmology; cataract and refractive surgery; ocular oncology; ophthalmic pathology; ophthalmic genetics.