Ebuka Elijah David, Ikechuku Okorie Igwenyi, Ifeanyichukwu Romanus Iroha, Layla Farage Martins, Guillermo Uceda-Campos, Aline Maria da Silva
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引用次数: 0
Abstract
Although an environmental contaminant, Alcaligenes sp. are now increasingly reported in clinical infections. Here, we present a whole-genome sequence of an extended spectrum beta-lactamase (ESBL) Alcaligenes nematophilus strain EBU-23 encoding beta-lactamase, bla gene, isolated from the stool of a hospitalized infant with acute gastroenteritis in a tertiary hospital in Nigeria. Antibiotics susceptibility test revealed that the isolate was resistant to the β-lactams, cephalosporins, and penicillin, β-lactam combination, and the fluoroquinolones. Genomic analysis exposed the presence of a class A beta-lactam hydrolase gene and multiple multidrug efflux permease which may be responsible for the beta-lactamase and multidrug resistance observed with the isolate. To the best our knowledge, we describe the first whole-genome sequence of a multidrug-resistant A. nematophilus implicated in acute childhood gastroenteritis in Nigeria.
尽管嗜线虫是一种环境污染物，但现在越来越多的临床感染病例报道了这种细菌。在此，我们展示了从尼日利亚一家三甲医院一名急性胃肠炎住院婴儿粪便中分离出的广谱β-内酰胺酶（ESBL）嗜线虫阿尔卡利肠杆菌菌株EBU-23的全基因组序列，该菌株编码β-内酰胺酶和la基因。抗生素药敏试验显示，该分离菌株对β-内酰胺类、头孢菌素类、青霉素、β-内酰胺类复方制剂和氟喹诺酮类药物具有耐药性。基因组分析显示，该分离株存在一个 A 类β-内酰胺水解酶基因和多个多药外排渗透酶，这可能是导致该分离株产生β-内酰胺酶和多药耐药性的原因。据我们所知，我们首次描述了尼日利亚儿童急性肠胃炎中出现的耐多药线虫的全基因组序列。
期刊介绍：
Current Microbiology is a well-established journal that publishes articles in all aspects of microbial cells and the interactions between the microorganisms, their hosts and the environment.
Current Microbiology publishes original research articles, short communications, reviews and letters to the editor, spanning the following areas:
physiology, biochemistry, genetics, genomics, biotechnology, ecology, evolution, morphology, taxonomy, diagnostic methods, medical and clinical microbiology and immunology as applied to microorganisms.
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