Cardiovascular disease modifies the relationship between systolic blood pressure and outcomes in people with diabetes

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2024-10-30 DOI:10.1016/j.diabres.2024.111909

Anping Cai , Jiabin Wang , Xiaoxuan Feng , Gianfranco Parati , Ji-Guang Wang , Yingqing Feng , Zhiqiang Nie

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引用次数: 0

Abstract

Objective

We aimed to evaluate the influences of cardiovascular disease (CVD) on the relationship between baseline systolic blood pressure (SBP) and outcomes in community populations with diabetes.

Methods

This is an observational study of 16,431 community adults with diabetes. The relationship between SBP with major adverse cardiovascular event (MACE) and all-cause death were evaluated using multivariable-adjusted Cox proportional hazard models and restricted cubic spline.

Results

After a median follow-up of 3.4 (IQR 2.6, 4.3) years, 2145 (13.1 %) MACE and 1025 (6.2 %) all-cause death occurred. In participants free of CVD, in reference to SBP < 120 mmHg group, the risks for MACE increased as SBP category (120–129, 130–139, and ≥ 140 mmHg) advanced (P-trend < 0.001), and there was a linear relationship (P-nonlinear = 0.75). The risks for all-cause death were lower in SBP of 120–139 mmHg and 140–159 mmHg groups but higher in SBP ≥ 160 mmHg group, and there was a U-shaped relationship (P-nonlinear < 0.001). In participants with existing CVD the relationship between baseline SBP with MACE and all-cause death did not show any specific pattern.

Conclusion

Results of the current study suggest that the relationship between baseline SBP with MACE and all-cause death varied significantly by baseline CVD status.

查看原文本刊更多论文

心血管疾病会改变收缩压与糖尿病患者预后之间的关系。

目的我们旨在评估心血管疾病（CVD）对社区糖尿病患者基线收缩压（SBP）和预后之间关系的影响：这是一项针对 16,431 名社区成人糖尿病患者的观察性研究。采用多变量调整后的 Cox 比例危险模型和限制性立方样条曲线评估了收缩压与主要不良心血管事件（MACE）和全因死亡之间的关系：中位随访 3.4（IQR 2.6，4.3）年后，发生了 2145 例（13.1%）MACE 和 1025 例（6.2%）全因死亡。在无心血管疾病的参与者中，参照 SBP < 120 mmHg 组，MACE 风险随着 SBP 类别（120-129、130-139 和 ≥ 140 mmHg）的升高而增加（P-趋势结论）：本研究结果表明，基线 SBP 与 MACE 和全因死亡之间的关系因基线心血管疾病状态的不同而存在显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.