Correlation Between Regulation of Intestinal Flora by Danggui-Shaoyao-San and Improvement of Cognitive Impairment in Mice With Alzheimer's Disease

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-10-31 DOI:10.1002/brb3.70110

Ya-Han Wang, Peng-Li Ding, Kai-Xin Zhang, Xiang-Qing Xu, He Li

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Abstract

Purpose

The abnormal central glucose metabolism in Alzheimer's disease (AD) is related to the brain–gut axis. This study aims to explore the target of Danggui-Shaoyao-San (DSS) in improving cognitive impairment.

Method

This study analyzed the differences in mice intestinal flora by 16S rRNA sequencing. The cognitive protective effects of DSS were observed through the Morris water maze and the new object recognition. The mitigation effects of DSS on Aβ and p-tau, regulatory effects on glucose metabolism targets, and intestinal structure effects were observed through brain and colon slices staining. The differences in neural ultrastructure were compared by transmission electron microscopy.

Finding

The results showed that DSS affected the composition of intestinal dominant bacteria and bacteria genera and regulated the abundance of intestinal bacteria in AD mice. DSS improved the behavior of AD mice, alleviated the deposition of AD pathological products in the brain and colon, regulated the expression of glycometabolism-related proteins, and improved the colon barrier structure and neural ultrastructure in the brain of mice with AD.

Conclusion

Our findings suggest that DSS may affect AD central glucose metabolism and improve cognition by regulating the gut–brain axis.

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当归芍药散调节肠道菌群与改善阿尔茨海默病小鼠认知障碍的相关性

目的：阿尔茨海默病（AD）的中枢糖代谢异常与脑肠轴有关。本研究旨在探讨当归芍药散（DSS）在改善认知障碍方面的作用靶点：方法：本研究通过 16S rRNA 测序分析了小鼠肠道菌群的差异。方法：本研究通过 16S rRNA 测序分析了小鼠肠道菌群的差异。通过脑片和结肠片染色观察了DSS对Aβ和p-tau的缓解作用、对葡萄糖代谢靶点的调节作用以及对肠道结构的影响。通过透射电子显微镜比较了神经超微结构的差异：结果表明，DSS影响了AD小鼠肠道优势菌和菌属的组成，并调节了肠道细菌的丰度。结果表明，DSS影响了AD小鼠肠道优势菌和菌属的组成，调节了肠道细菌的丰度，改善了AD小鼠的行为，减轻了AD病理产物在大脑和结肠中的沉积，调节了糖代谢相关蛋白的表达，改善了AD小鼠结肠屏障结构和大脑神经超微结构：我们的研究结果表明，DSS可通过调节肠脑轴影响AD中枢糖代谢并改善认知能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464