Risk factors of cholangiocarcinoma in areas not endemic for liver fluke infection.

IF 0.4 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Asian Biomedicine Pub Date : 2024-10-31 eCollection Date: 2024-10-01 DOI:10.2478/abm-2024-0028

Tongluk Teerasarntipan, Pawat Phuensan, Chonlada Phathong, Somchai Pinlaor, Parit Mekaroonkamol, Roongruedee Chaiteerakij

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引用次数: 0

Abstract

Background: Thailand has the world's highest prevalence of cholangiocarcinoma (CCA), especially in the endemic area of liver fluke Opisthorchis viverrini infection. However, other regions of Thailand still have relatively high CCA prevalence.

Objectives: We aimed to determine CCA risk factors in areas not endemic for OV infection.

Methods: A case--control study was performed at a referral center during December 2016-December 2017. We collected blood samples and information from CCA patients and identified them as cases. The control group comprised patients who visited a gastrointestinal clinic for colorectal cancer screening colonoscopy. Logistic regression analysis was used to determine risk factors for CCA.

Results: Of 138 participants, O. viverrini infection rate was higher in the case than in the control group (57.1% vs. 36.1%, P = 0.023). Male, O. viverrini infection, smoking, alcohol consumption, and biliary tract diseases were independent risk factors, whereas diabetes, obesity, and cirrhosis were not associated with CCA. By age and sex-adjusted analysis, chronic biliary tract diseases, especially choledochal cysts and smoking, were risk factors for CCA, with adjusted odds ratio (aOR) of 12.7 (95% confidence interval [CI]: 1.4-116.9) and 3.8 (95% CI: 1.3-11.8), respectively, while O. viverrini infection became insignificant risk for CCA (aOR 1.8, 95% CI: 0.8-4.1).

Conclusions: In contrast with endemic areas for O. viverrini infection, chronic biliary tract diseases and smoking are major risk factors, whereas O. viverrini infection has trivial contribution to the development of CCA.

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肝吸虫感染非流行地区胆管癌的风险因素。

背景：泰国是世界上胆管癌（CCA）发病率最高的国家，尤其是在肝吸虫感染流行区。然而，泰国其他地区的 CCA 发病率仍然相对较高：我们旨在确定非OV感染流行地区的CCA风险因素：方法：2016 年 12 月至 2017 年 12 月期间，我们在一家转诊中心开展了一项病例对照研究。我们收集了CCA患者的血样和信息，并将其确定为病例。对照组由到胃肠门诊进行结直肠癌筛查结肠镜检查的患者组成。采用逻辑回归分析确定CCA的风险因素：138名参与者中，病例组的O. viverrini感染率高于对照组（57.1% vs. 36.1%，P = 0.023）。男性、O. viverrini感染、吸烟、饮酒和胆道疾病是独立的风险因素，而糖尿病、肥胖和肝硬化与CCA无关。根据年龄和性别调整分析，慢性胆道疾病，尤其是胆总管囊肿和吸烟，是CCA的危险因素，调整后的几率比（aOR）分别为12.7（95% 置信区间[CI]：1.4-116.9）和3.8（95% CI：1.3-11.8），而O. viverrini感染成为CCA的微小危险因素（aOR 1.8，95% CI：0.8-4.1）：结论：与O. viverrini感染流行地区相比，慢性胆道疾病和吸烟是CCA的主要风险因素，而O. viverrini感染对CCA的发病影响微乎其微。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Biomedicine 医学-医学：研究与实验

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Asian Biomedicine: Research, Reviews and News (ISSN 1905-7415 print; 1875-855X online) is published in one volume (of 6 bimonthly issues) a year since 2007. [...]Asian Biomedicine is an international, general medical and biomedical journal that aims to publish original peer-reviewed contributions dealing with various topics in the biomedical and health sciences from basic experimental to clinical aspects. The work and authorship must be strongly affiliated with a country in Asia, or with specific importance and relevance to the Asian region. The Journal will publish reviews, original experimental studies, observational studies, technical and clinical (case) reports, practice guidelines, historical perspectives of Asian biomedicine, clinicopathological conferences, and commentaries Asian biomedicine is intended for a broad and international audience, primarily those in the health professions including researchers, physician practitioners, basic medical scientists, dentists, educators, administrators, those in the assistive professions, such as nurses, and the many types of allied health professionals in research and health care delivery systems including those in training.